DegronMD

Uniprot ID: Q8NET4

Source protein: Retrotransposon Gag-like protein 9

Source gene: RTL9

Class: DEG_SCF_FBW7_1

Location: 294:300

E3 ligase: FBXW7

DEGRON score: 0.9867

ASA_SCORE: 87.6714

COIL: 0.9163

CONS_SCORE: 0.4889

DSS_SCORE: 0.6261

HELIX: 0.0313

FCONS_SCORE: 1.1874

RIG_SCORE: 0.7003

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G293R	SIDM00522	Small Cell Lung Carcinoma	GDSC	IPTPLMS	DEG_SCF_FBW7_1	0.3056
p.G293R	SIDM00140	Melanoma	GDSC	IPTPLMS	DEG_SCF_FBW7_1	0.3056
p.G293R	DMS-273	lung	COSMIC	IPTPLMS	DEG_SCF_FBW7_1	0.3056
p.G293R	COLO-792	skin	COSMIC	IPTPLMS	DEG_SCF_FBW7_1	0.3056
p.G293E	SIDM00221	Melanoma	GDSC	IPTPLMS	DEG_SCF_FBW7_1	0.3056
p.S287N	HCT-15	large_intestine	COSMIC	IPTPLMS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NET4	Retrotransposon Gag-like protein 9	DEG_SCF_FBW7_1	294:300	IPTPLMS	FBXW7	0.9867	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons