DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
ARSTS
Uniprot ID:
Q8NET4
Source protein:
Retrotransposon Gag-like protein 9
Source gene:
RTL9
Class:
DEG_SPOP_SBC_1
Location:
1026:1030
E3 ligase:
SPOP
DEGRON score:
0.702
ASA_SCORE:
93.8
COIL:
0.8906
CONS_SCORE:
0.5435
DSS_SCORE:
0.4459
HELIX:
0.0542
FCONS_SCORE:
1.1778
RIG_SCORE:
0.6865
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A1026T
SIDM00007
Other Solid Cancers
GDSC
ARSTS
DEG_SPOP_SBC_1
0.7139
p.A1026T
MCC13
skin
COSMIC
ARSTS
DEG_SPOP_SBC_1
0.7139
Drug responses associated with RTL9 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ARSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O00409
Forkhead box protein N3
DEG_SPOP_SBC_1
345:349
ARSTS
SPOP
0.9829
More...
O14874
[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
DEG_SPOP_SBC_1
29:33
ARSTS
SPOP
0.999
More...
Q6ZSM3
Monocarboxylate transporter 12
DEG_SPOP_SBC_1
37:41
ARSTS
SPOP
0.6242
More...
Q9H3R0
Lysine-specific demethylase 4C
DEG_SPOP_SBC_1
376:380
ARSTS
SPOP
0.9041
More...
Q9BXK1
Krueppel-like factor 16
DEG_SPOP_SBC_1
222:226
ARSTS
SPOP
0.9312
More...
Q8NET4
Retrotransposon Gag-like protein 9
DEG_SPOP_SBC_1
1026:1030
ARSTS
SPOP
0.702
More...