DegronMD

Uniprot ID: O14874

Source protein: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial

Source gene: BCKDK

Class: DEG_SPOP_SBC_1

Location: 29:33

E3 ligase: SPOP

DEGRON score: 0.999

ASA_SCORE: 74.52

COIL: 0.8198

CONS_SCORE: 0.3477

DSS_SCORE: 0.4469

HELIX: 0.0998

FCONS_SCORE: 1.1842

RIG_SCORE: 0.6727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A34S	TCGA-AR-A251	BRCA	TCGA	ARSTS	DEG_SPOP_SBC_1	0.3056
p.A34S	DO5724	BRCA	ICGC	ARSTS	DEG_SPOP_SBC_1	0.3056
p.R30C	TCGA-CK-5913	COAD	TCGA	ARSTS	DEG_SPOP_SBC_1	0.719
p.R30C	DO8826	COAD	ICGC	ARSTS	DEG_SPOP_SBC_1	0.719
p.P23S	TCGA-CV-7568	HNSC	TCGA	ARSTS	DEG_SPOP_SBC_1	0.1667
p.P23S	DO14160	HNSC	ICGC	ARSTS	DEG_SPOP_SBC_1	0.1667
p.A24T	TCGA-FI-A2D5	UCEC	TCGA	ARSTS	DEG_SPOP_SBC_1	0.1944
p.A24T	TCGA-FS-A1ZT	SKCM	TCGA	ARSTS	DEG_SPOP_SBC_1	0.1944
p.A24T	DO37468	SKCM	ICGC	ARSTS	DEG_SPOP_SBC_1	0.1944
p.A24T	DO41331	UCEC	ICGC	ARSTS	DEG_SPOP_SBC_1	0.1944
p.A26V	TCGA-VQ-A8PT	STAD	TCGA	ARSTS	DEG_SPOP_SBC_1	0.25
p.A26V	DO233867	GACA	ICGC	ARSTS	DEG_SPOP_SBC_1	0.25
p.A26V	DO51776	STAD	ICGC	ARSTS	DEG_SPOP_SBC_1	0.25
p.L21R	DO234404	ESAD	ICGC	ARSTS	DEG_SPOP_SBC_1	0.1111
p.A24S	DO229037	LICA	ICGC	ARSTS	DEG_SPOP_SBC_1	0.1944
p.V40M	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	0.1389
p.V40M	ACH-000924	Lung Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	0.1389
p.R30H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ARSTS	DEG_SPOP_SBC_1	0.7133
p.R30H	ACH-002256	Leukemia	CCLE	ARSTS	DEG_SPOP_SBC_1	0.7133
p.R30H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00409	Forkhead box protein N3	DEG_SPOP_SBC_1	345:349	ARSTS	SPOP	0.9829	More...
O14874	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	DEG_SPOP_SBC_1	29:33	ARSTS	SPOP	0.999	More...
Q6ZSM3	Monocarboxylate transporter 12	DEG_SPOP_SBC_1	37:41	ARSTS	SPOP	0.6242	More...
Q9H3R0	Lysine-specific demethylase 4C	DEG_SPOP_SBC_1	376:380	ARSTS	SPOP	0.9041	More...
Q9BXK1	Krueppel-like factor 16	DEG_SPOP_SBC_1	222:226	ARSTS	SPOP	0.9312	More...
Q8NET4	Retrotransposon Gag-like protein 9	DEG_SPOP_SBC_1	1026:1030	ARSTS	SPOP	0.702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons