DegronMD

Uniprot ID: Q9H3R0

Source protein: Lysine-specific demethylase 4C

Source gene: KDM4C

Class: DEG_SPOP_SBC_1

Location: 376:380

E3 ligase: SPOP

DEGRON score: 0.9041

ASA_SCORE: 104.68

COIL: 0.825

CONS_SCORE: 0.3015

DSS_SCORE: 0.5917

HELIX: 0.1646

FCONS_SCORE: 0.9814

RIG_SCORE: 0.6542

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A376S	TCGA-50-5049	LUAD	TCGA	ARSTS	DEG_SPOP_SBC_1	0.7588
p.A376S	DO23705	LUAD	ICGC	ARSTS	DEG_SPOP_SBC_1	0.7588
p.K381I	TCGA-78-8662	LUAD	TCGA	ARSTS	DEG_SPOP_SBC_1	0.3056
p.K381I	DO45346	LUAD	ICGC	ARSTS	DEG_SPOP_SBC_1	0.3056
p.T379I	TCGA-B5-A11E	UCEC	TCGA	ARSTS	DEG_SPOP_SBC_1	0.7078
p.T379I	DO41644	UCEC	ICGC	ARSTS	DEG_SPOP_SBC_1	0.7078
p.E387D	TCGA-CR-7402	HNSC	TCGA	ARSTS	DEG_SPOP_SBC_1	0.1389
p.E387D	DO15727	HNSC	ICGC	ARSTS	DEG_SPOP_SBC_1	0.1389
p.R382S	TCGA-DX-A6YS	SARC	TCGA	ARSTS	DEG_SPOP_SBC_1	0.2778
p.R382S	DO220005	SARC	ICGC	ARSTS	DEG_SPOP_SBC_1	0.2778
p.R377M	TCGA-ER-A19P	SKCM	TCGA	ARSTS	DEG_SPOP_SBC_1	0.7521
p.R377M	DO47623	SKCM	ICGC	ARSTS	DEG_SPOP_SBC_1	0.7521
p.S370F	TCGA-FR-A8YC	SKCM	TCGA	ARSTS	DEG_SPOP_SBC_1	0.1667
p.S370F	DO50301	SKCM	ICGC	ARSTS	DEG_SPOP_SBC_1	0.1667
p.P383H	TCGA-G4-6588	COAD	TCGA	ARSTS	DEG_SPOP_SBC_1	0.25
p.P383H	DO10140	COAD	ICGC	ARSTS	DEG_SPOP_SBC_1	0.25
p.R371Q	DO222884	COCA	ICGC	ARSTS	DEG_SPOP_SBC_1	0.1944
p.A369S	SIDM00336	Melanoma	GDSC	ARSTS	DEG_SPOP_SBC_1	0.1389
p.A369S	ACH-000881	Skin Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	0.1389
p.A369S	MEL-JUSO	skin	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.1389
p.F373L	SIDM01196	Hepatocellular Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	0.25
p.F373L	SIDM01564	Colorectal Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	0.25
p.F373L	SNU-475	liver	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.25
p.A376V	SIDM01146	Gastric Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	0.5825
p.A376V	ACH-000932	Gastric Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	0.5825
p.A376V	NCI-SNU-1	stomach	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.5825
p.D366E	NCI-H2066	lung	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.0556
p.T371I	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00409	Forkhead box protein N3	DEG_SPOP_SBC_1	345:349	ARSTS	SPOP	0.9829	More...
O14874	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	DEG_SPOP_SBC_1	29:33	ARSTS	SPOP	0.999	More...
Q6ZSM3	Monocarboxylate transporter 12	DEG_SPOP_SBC_1	37:41	ARSTS	SPOP	0.6242	More...
Q9H3R0	Lysine-specific demethylase 4C	DEG_SPOP_SBC_1	376:380	ARSTS	SPOP	0.9041	More...
Q9BXK1	Krueppel-like factor 16	DEG_SPOP_SBC_1	222:226	ARSTS	SPOP	0.9312	More...
Q8NET4	Retrotransposon Gag-like protein 9	DEG_SPOP_SBC_1	1026:1030	ARSTS	SPOP	0.702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARSTS

Degron related mutations and impact score

Drug responses associated with KDM4C mutations

All proteins holding degron of ARSTS