DegronMD

Uniprot ID: Q6ZSM3

Source protein: Monocarboxylate transporter 12

Source gene: SLC16A12

Class: DEG_SPOP_SBC_1

Location: 37:41

E3 ligase: SPOP

DEGRON score: 0.6242

ASA_SCORE: 96.26

COIL: 0.8914

CONS_SCORE: 0.5949

DSS_SCORE: 0.4584

HELIX: 0.0766

FCONS_SCORE: 1.3466

RIG_SCORE: 0.6902

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G48C	TCGA-55-7907	LUAD	TCGA	ARSTS	DEG_SPOP_SBC_1	0.1389
p.V34I	TCGA-E6-A1LX	UCEC	TCGA	ARSTS	DEG_SPOP_SBC_1	0.25
p.T30A	TCGA-EO-A22R	UCEC	TCGA	ARSTS	DEG_SPOP_SBC_1	0.1389
p.T30A	DO42713	UCEC	ICGC	ARSTS	DEG_SPOP_SBC_1	0.1389
p.T30A	ACH-001570	Skin Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	0.1389
p.R38W	TCGA-W3-A828	SKCM	TCGA	ARSTS	DEG_SPOP_SBC_1	0.7523
p.R38W	SIDM00892	Breast Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	0.7523
p.R38W	ACH-000818	Breast Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	0.7523
p.R38W	BT-483	breast	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.7523
p.I41F	DO7828	COAD	ICGC	ARSTS	DEG_SPOP_SBC_1	0.7415
p.T51A	DO233697	GACA	ICGC	ARSTS	DEG_SPOP_SBC_1	0.0556
p.F46L	DO229024	LICA	ICGC	ARSTS	DEG_SPOP_SBC_1	0.1944
p.T51N	DO229038	LICA	ICGC	ARSTS	DEG_SPOP_SBC_1	0.0556
p.R28K	DO229051	LICA	ICGC	ARSTS	DEG_SPOP_SBC_1	0.0833
p.T48I	DO224563	LUSC	ICGC	ARSTS	DEG_SPOP_SBC_1	0.1389
p.R28T	DO46368	OV	ICGC	ARSTS	DEG_SPOP_SBC_1	0.0833
p.A32S	SIDM00697	Small Cell Lung Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	0.1944
p.A32S	ACH-000830	Lung Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	0.1944
p.A32S	NCI-H1436	lung	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.1944
p.K33E	SIDM00773	Non-Cancerous	GDSC	ARSTS	DEG_SPOP_SBC_1	0.3333
p.K33E	SIDM00774	Breast Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	0.3333
p.P42L	SIDM00967	Ovarian Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	0.3056
p.P42L	ACH-002181	Ovarian Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	0.3056
p.P42L	OVCA420	ovary	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00409	Forkhead box protein N3	DEG_SPOP_SBC_1	345:349	ARSTS	SPOP	0.9829	More...
O14874	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	DEG_SPOP_SBC_1	29:33	ARSTS	SPOP	0.999	More...
Q6ZSM3	Monocarboxylate transporter 12	DEG_SPOP_SBC_1	37:41	ARSTS	SPOP	0.6242	More...
Q9H3R0	Lysine-specific demethylase 4C	DEG_SPOP_SBC_1	376:380	ARSTS	SPOP	0.9041	More...
Q9BXK1	Krueppel-like factor 16	DEG_SPOP_SBC_1	222:226	ARSTS	SPOP	0.9312	More...
Q8NET4	Retrotransposon Gag-like protein 9	DEG_SPOP_SBC_1	1026:1030	ARSTS	SPOP	0.702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons