DegronMD - Q6ZSM3(SLC16A12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G48C	TCGA-55-7907	LUAD	TCGA	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.1389
p.V34I	TCGA-E6-A1LX	UCEC	TCGA	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.25
p.T30A	TCGA-EO-A22R	UCEC	TCGA	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.1389
p.T30A	DO42713	UCEC	ICGC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.1389
p.T30A	ACH-001570	Skin Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.1389
p.R38W	TCGA-W3-A828	SKCM	TCGA	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.7523
p.R38W	SIDM00892	Breast Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.7523
p.R38W	ACH-000818	Breast Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.7523
p.R38W	BT-483	breast	COSMIC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.7523
p.I41F	DO7828	COAD	ICGC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.7415
p.T51A	DO233697	GACA	ICGC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.0556
p.F46L	DO229024	LICA	ICGC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.1944
p.T51N	DO229038	LICA	ICGC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.0556
p.R28K	DO229051	LICA	ICGC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.0833
p.T48I	DO224563	LUSC	ICGC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.1389
p.R28T	DO46368	OV	ICGC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.0833
p.A32S	SIDM00697	Small Cell Lung Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.1944
p.A32S	ACH-000830	Lung Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.1944
p.A32S	NCI-H1436	lung	COSMIC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.1944
p.K33E	SIDM00773	Non-Cancerous	GDSC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation substituting flanking lysine	0.3333
p.K33E	SIDM00774	Breast Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation substituting flanking lysine	0.3333
p.P42L	SIDM00967	Ovarian Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.3056
p.P42L	ACH-002181	Ovarian Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.3056
p.P42L	OVCA420	ovary	COSMIC	ARSTS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.3056

Kaplan plot for SLC16A12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC16A12

UniProt ID: Q6ZSM3

Entrez ID: 387700

Protein name: Monocarboxylate transporter 12 (MCT 12) (Creatine transporter 2) (CRT2) (Solute carrier family 16 member 12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC16A12 in