DegronMD

Uniprot ID: O00409

Source protein: Forkhead box protein N3

Source gene: FOXN3

Class: DEG_SPOP_SBC_1

Location: 345:349

E3 ligase: SPOP

DEGRON score: 0.9829

ASA_SCORE: 95.76

COIL: 0.9558

CONS_SCORE: 0.5778

DSS_SCORE: 0.5878

HELIX: 0.026

FCONS_SCORE: 0.9511

RIG_SCORE: 0.5475

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A340D	TCGA-AA-3821	COAD	TCGA	ARSTS	DEG_SPOP_SBC_1	0.1944
p.T348I	DO229446	SKCA	ICGC	ARSTS	DEG_SPOP_SBC_1	0.7078
p.E356K	DO41799	UCEC	ICGC	ARSTS	DEG_SPOP_SBC_1	0.1389
p.R346W	SIDM00333	Endometrial Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	0.7523
p.R346W	ACH-000988	Endometrial/Uterine Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	0.7523
p.R346W	MFE-319	endometrium	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.7523
p.S358F	SIDM00516	Melanoma	GDSC	ARSTS	DEG_SPOP_SBC_1	0.0833
p.S358F	ACH-002166	Skin Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	0.0833
p.S358F	MZ7-mel	skin	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.0833
p.E353K	EW-22	bone	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.2222
p.E345G	TK	haematopoietic_and_lymphoid_tissue	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.7199
p.D341N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.3333
p.D341N	SNU-1040	large_intestine	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.3333
p.S336F	MZ7-mel	skin	COSMIC	ARSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00409	Forkhead box protein N3	DEG_SPOP_SBC_1	345:349	ARSTS	SPOP	0.9829	More...
O14874	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	DEG_SPOP_SBC_1	29:33	ARSTS	SPOP	0.999	More...
Q6ZSM3	Monocarboxylate transporter 12	DEG_SPOP_SBC_1	37:41	ARSTS	SPOP	0.6242	More...
Q9H3R0	Lysine-specific demethylase 4C	DEG_SPOP_SBC_1	376:380	ARSTS	SPOP	0.9041	More...
Q9BXK1	Krueppel-like factor 16	DEG_SPOP_SBC_1	222:226	ARSTS	SPOP	0.9312	More...
Q8NET4	Retrotransposon Gag-like protein 9	DEG_SPOP_SBC_1	1026:1030	ARSTS	SPOP	0.702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons