DegronMD - O00409(FOXN3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R421C	TCGA-2W-A8YY	CESC	TCGA	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation rewiring degron network	0.1944
p.R421C	TCGA-BR-8360	STAD	TCGA	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation rewiring degron network	0.1944
p.S416F	TCGA-77-8145	LUSC	TCGA	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation altering degron motif	0.7982
p.A340D	TCGA-AA-3821	COAD	TCGA	ARSTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.1944
p.S408Y	TCGA-AX-A05Z	UCEC	TCGA	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation rewiring degron network	0.25
p.K406N	TCGA-BT-A20T	BLCA	TCGA	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation substituting flanking lysine	0.3056
p.R419H	DO222960	BTCA	ICGC	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation substituting flanking lysine	0.3611
p.R419H	DO42673	UCEC	ICGC	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation substituting flanking lysine	0.3611
p.P414S	DO9346	COAD	ICGC	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation altering degron motif	0.6752
p.K407E	DO8264	COAD	ICGC	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation rewiring degron network	0.2222
p.S410R	DO228948	LICA	ICGC	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation rewiring degron network	0.3056
p.S410R	DO228985	LICA	ICGC	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation rewiring degron network	0.3056
p.P423T	DO229008	LICA	ICGC	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation rewiring degron network	0.1389
p.T412I	DO28004	OV	ICGC	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation altering degron motif	0.7078
p.T348I	DO229446	SKCA	ICGC	ARSTS	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7078
p.E425K	DO43274	UCEC	ICGC	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation rewiring degron network	0.0833
p.E356K	DO41799	UCEC	ICGC	ARSTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.1389
p.R346W	SIDM00333	Endometrial Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7523
p.R346W	ACH-000988	Endometrial/Uterine Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7523
p.R346W	MFE-319	endometrium	COSMIC	ARSTS	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7523
p.S358F	SIDM00516	Melanoma	GDSC	ARSTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.S358F	ACH-002166	Skin Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.S358F	MZ7-mel	skin	COSMIC	ARSTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833
p.A415T	SIDM01609	Endometrial Carcinoma	GDSC	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation altering degron motif	0.6028
p.Y414C	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGYAS	DEG_SCF_TRCP1_1	411:416	Mutation altering degron motif	0.5976
p.E353K	EW-22	bone	COSMIC	ARSTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.2222
p.E345G	TK	haematopoietic and lymphoid tissue	COSMIC	ARSTS	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7199
p.D341N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ARSTS	DEG_SPOP_SBC_1	345:349	Mutation substituting flanking lysine	0.3333
p.D341N	SNU-1040	large intestine	COSMIC	ARSTS	DEG_SPOP_SBC_1	345:349	Mutation substituting flanking lysine	0.3333
p.S336F	MZ7-mel	skin	COSMIC	ARSTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0833

Kaplan plot for FOXN3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXN3

UniProt ID: O00409

Entrez ID: 1112

Protein name: Forkhead box protein N3 (Checkpoint suppressor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXN3 in