DegronMD

Uniprot ID: O00409

Source protein: Forkhead box protein N3

Source gene: FOXN3

Class: DEG_SCF_TRCP1_1

Location: 411:416

E3 ligase: BTRC

DEGRON score: 0.9803

ASA_SCORE: 70.3167

COIL: 0.648

CONS_SCORE: 0.6004

DSS_SCORE: 0.7775

HELIX: 0.3282

FCONS_SCORE: 1.0901

RIG_SCORE: 0.564

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R421C	TCGA-2W-A8YY	CESC	TCGA	DSGYAS	DEG_SCF_TRCP1_1	0.1944
p.R421C	TCGA-BR-8360	STAD	TCGA	DSGYAS	DEG_SCF_TRCP1_1	0.1944
p.S416F	TCGA-77-8145	LUSC	TCGA	DSGYAS	DEG_SCF_TRCP1_1	0.7982
p.S408Y	TCGA-AX-A05Z	UCEC	TCGA	DSGYAS	DEG_SCF_TRCP1_1	0.25
p.K406N	TCGA-BT-A20T	BLCA	TCGA	DSGYAS	DEG_SCF_TRCP1_1	0.3056
p.R419H	DO222960	BTCA	ICGC	DSGYAS	DEG_SCF_TRCP1_1	0.3611
p.R419H	DO42673	UCEC	ICGC	DSGYAS	DEG_SCF_TRCP1_1	0.3611
p.P414S	DO9346	COAD	ICGC	DSGYAS	DEG_SCF_TRCP1_1	0.6752
p.K407E	DO8264	COAD	ICGC	DSGYAS	DEG_SCF_TRCP1_1	0.2222
p.S410R	DO228948	LICA	ICGC	DSGYAS	DEG_SCF_TRCP1_1	0.3056
p.S410R	DO228985	LICA	ICGC	DSGYAS	DEG_SCF_TRCP1_1	0.3056
p.P423T	DO229008	LICA	ICGC	DSGYAS	DEG_SCF_TRCP1_1	0.1389
p.T412I	DO28004	OV	ICGC	DSGYAS	DEG_SCF_TRCP1_1	0.7078
p.E425K	DO43274	UCEC	ICGC	DSGYAS	DEG_SCF_TRCP1_1	0.0833
p.A415T	SIDM01609	Endometrial Carcinoma	GDSC	DSGYAS	DEG_SCF_TRCP1_1	0.6028
p.Y414C	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGYAS	DEG_SCF_TRCP1_1	0.5976

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00409	Forkhead box protein N3	DEG_SCF_TRCP1_1	411:416	DSGYAS	BTRC	0.9803	More...
Q8N350	Voltage-dependent calcium channel beta subunit-associated regulatory protein	DEG_SCF_TRCP1_1	502:507	DSGYAS	BTRC	0.9343	More...
P32314	Forkhead box protein N2	DEG_SCF_TRCP1_1	364:369	DSGYAS	BTRC	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons