DegronMD

Uniprot ID: P32314

Source protein: Forkhead box protein N2

Source gene: FOXN2

Class: DEG_SCF_TRCP1_1

Location: 364:369

E3 ligase: BTRC

DEGRON score: 0.9941

ASA_SCORE: 62.1333

COIL: 0.8108

CONS_SCORE: 0.5278

DSS_SCORE: 0.5876

HELIX: 0.088

FCONS_SCORE: 0.9974

RIG_SCORE: 0.6611

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P371R	TCGA-5M-AAT4	COAD	TCGA	DSGYAS	DEG_SCF_TRCP1_1	0.2778
p.P371R	DO223702	COAD	ICGC	DSGYAS	DEG_SCF_TRCP1_1	0.2778
p.D360N	TCGA-GC-A3RB	BLCA	TCGA	DSGYAS	DEG_SCF_TRCP1_1	0.2222
p.D360N	DO530	BLCA	ICGC	DSGYAS	DEG_SCF_TRCP1_1	0.2222
p.P371S	TCGA-VQ-A8PX	STAD	TCGA	DSGYAS	DEG_SCF_TRCP1_1	0.2778
p.P371S	DO51778	STAD	ICGC	DSGYAS	DEG_SCF_TRCP1_1	0.2778
p.G363A	SIDM01042	Breast Carcinoma	GDSC	DSGYAS	DEG_SCF_TRCP1_1	0.3056
p.G363A	ACH-001065	Breast Cancer	CCLE	DSGYAS	DEG_SCF_TRCP1_1	0.3056
p.G363A	EVSA-T	breast	COSMIC	DSGYAS	DEG_SCF_TRCP1_1	0.3056
p.P361L	ACH-001409	Bladder Cancer	CCLE	DSGYAS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00409	Forkhead box protein N3	DEG_SCF_TRCP1_1	411:416	DSGYAS	BTRC	0.9803	More...
Q8N350	Voltage-dependent calcium channel beta subunit-associated regulatory protein	DEG_SCF_TRCP1_1	502:507	DSGYAS	BTRC	0.9343	More...
P32314	Forkhead box protein N2	DEG_SCF_TRCP1_1	364:369	DSGYAS	BTRC	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons