DegronMD - P32314(FOXN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P371R	TCGA-5M-AAT4	COAD	TCGA	DSGYAS	DEG_SCF_TRCP1_1	364:369	Mutation rewiring degron network	0.2778
p.P371R	DO223702	COAD	ICGC	DSGYAS	DEG_SCF_TRCP1_1	364:369	Mutation rewiring degron network	0.2778
p.K106Q	TCGA-CA-6717	COAD	TCGA	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation substituting flanking lysine	0.1667
p.K106Q	DO8264	COAD	ICGC	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation substituting flanking lysine	0.1667
p.P94S	TCGA-CK-4951	COAD	TCGA	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation altering degron motif	0.6752
p.P94S	DO10582	COAD	ICGC	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation altering degron motif	0.6752
p.I88T	TCGA-CZ-5465	KIRC	TCGA	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation altering degron motif	0.5966
p.I88T	DO17502	KIRC	ICGC	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation altering degron motif	0.5966
p.Y86H	TCGA-DU-6392	LGG	TCGA	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation rewiring degron network	0.3056
p.Y86H	DO22237	LGG	ICGC	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation rewiring degron network	0.3056
p.Y86H	SIDM00602	Gastric Carcinoma	GDSC	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation rewiring degron network	0.3056
p.Y86H	IM-95	stomach	COSMIC	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation rewiring degron network	0.3056
p.D360N	TCGA-GC-A3RB	BLCA	TCGA	DSGYAS	DEG_SCF_TRCP1_1	364:369	Mutation rewiring degron network	0.2222
p.D360N	DO530	BLCA	ICGC	DSGYAS	DEG_SCF_TRCP1_1	364:369	Mutation rewiring degron network	0.2222
p.I81V	TCGA-UY-A78N	BLCA	TCGA	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation rewiring degron network	0.1667
p.I81V	DO219034	BLCA	ICGC	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation rewiring degron network	0.1667
p.P371S	TCGA-VQ-A8PX	STAD	TCGA	DSGYAS	DEG_SCF_TRCP1_1	364:369	Mutation rewiring degron network	0.2778
p.P371S	DO51778	STAD	ICGC	DSGYAS	DEG_SCF_TRCP1_1	364:369	Mutation rewiring degron network	0.2778
p.G78C	DO227779	COCA	ICGC	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation rewiring degron network	0.0833
p.C100Y	DO233766	GACA	ICGC	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation rewiring degron network	0.2222
p.G78S	DO228972	LICA	ICGC	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation rewiring degron network	0.0833
p.V82F	DO228971	LICA	ICGC	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation rewiring degron network	0.1944
p.V93L	DO229037	LICA	ICGC	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation altering degron motif	0.6765
p.P98R	DO231737	LINC	ICGC	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation rewiring degron network	0.2778
p.P94T	DO50727	ORCA	ICGC	DIEGDDVPSF	DEG_COP1_1	87:96	Mutation altering degron motif	0.7031
p.G363A	SIDM01042	Breast Carcinoma	GDSC	DSGYAS	DEG_SCF_TRCP1_1	364:369	Mutation rewiring degron network	0.3056
p.G363A	ACH-001065	Breast Cancer	CCLE	DSGYAS	DEG_SCF_TRCP1_1	364:369	Mutation rewiring degron network	0.3056
p.G363A	EVSA-T	breast	COSMIC	DSGYAS	DEG_SCF_TRCP1_1	364:369	Mutation rewiring degron network	0.3056
p.P361L	ACH-001409	Bladder Cancer	CCLE	DSGYAS	DEG_SCF_TRCP1_1	364:369	Mutation rewiring degron network	0.25

Kaplan plot for FOXN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXN2

UniProt ID: P32314

Entrez ID: 3344

Protein name: Forkhead box protein N2 (Human T-cell leukemia virus enhancer factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXN2 in