DegronMD

Uniprot ID: P32314

Source protein: Forkhead box protein N2

Source gene: FOXN2

Class: DEG_COP1_1

Location: 87:96

E3 ligase: COP1

DEGRON score: 0.952

ASA_SCORE: 82.35

COIL: 0.94

CONS_SCORE: 0.5755

DSS_SCORE: 0.3379

HELIX: 0.0336

FCONS_SCORE: 0.9784

RIG_SCORE: 0.7419

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K106Q	TCGA-CA-6717	COAD	TCGA	DIEGDDVPSF	DEG_COP1_1	0.1667
p.K106Q	DO8264	COAD	ICGC	DIEGDDVPSF	DEG_COP1_1	0.1667
p.P94S	TCGA-CK-4951	COAD	TCGA	DIEGDDVPSF	DEG_COP1_1	0.6752
p.P94S	DO10582	COAD	ICGC	DIEGDDVPSF	DEG_COP1_1	0.6752
p.I88T	TCGA-CZ-5465	KIRC	TCGA	DIEGDDVPSF	DEG_COP1_1	0.5966
p.I88T	DO17502	KIRC	ICGC	DIEGDDVPSF	DEG_COP1_1	0.5966
p.Y86H	TCGA-DU-6392	LGG	TCGA	DIEGDDVPSF	DEG_COP1_1	0.3056
p.Y86H	DO22237	LGG	ICGC	DIEGDDVPSF	DEG_COP1_1	0.3056
p.Y86H	SIDM00602	Gastric Carcinoma	GDSC	DIEGDDVPSF	DEG_COP1_1	0.3056
p.Y86H	IM-95	stomach	COSMIC	DIEGDDVPSF	DEG_COP1_1	0.3056
p.I81V	TCGA-UY-A78N	BLCA	TCGA	DIEGDDVPSF	DEG_COP1_1	0.1667
p.I81V	DO219034	BLCA	ICGC	DIEGDDVPSF	DEG_COP1_1	0.1667
p.G78C	DO227779	COCA	ICGC	DIEGDDVPSF	DEG_COP1_1	0.0833
p.C100Y	DO233766	GACA	ICGC	DIEGDDVPSF	DEG_COP1_1	0.2222
p.G78S	DO228972	LICA	ICGC	DIEGDDVPSF	DEG_COP1_1	0.0833
p.V82F	DO228971	LICA	ICGC	DIEGDDVPSF	DEG_COP1_1	0.1944
p.V93L	DO229037	LICA	ICGC	DIEGDDVPSF	DEG_COP1_1	0.6765
p.P98R	DO231737	LINC	ICGC	DIEGDDVPSF	DEG_COP1_1	0.2778
p.P94T	DO50727	ORCA	ICGC	DIEGDDVPSF	DEG_COP1_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P32314	Forkhead box protein N2	DEG_COP1_1	87:96	DIEGDDVPSF	COP1	0.952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons