DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
DSGYAS
Uniprot ID:
Q8N350
Source protein:
Voltage-dependent calcium channel beta subunit-associated regulatory protein
Source gene:
CBARP
Class:
DEG_SCF_TRCP1_1
Location:
502:507
E3 ligase:
BTRC
DEGRON score:
0.9343
ASA_SCORE:
64.75
COIL:
0.8102
CONS_SCORE:
0.3488
DSS_SCORE:
0.6869
HELIX:
0.1123
FCONS_SCORE:
0.7211
RIG_SCORE:
0.6409
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CBARP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGYAS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O00409
Forkhead box protein N3
DEG_SCF_TRCP1_1
411:416
DSGYAS
BTRC
0.9803
More...
Q8N350
Voltage-dependent calcium channel beta subunit-associated regulatory protein
DEG_SCF_TRCP1_1
502:507
DSGYAS
BTRC
0.9343
More...
P32314
Forkhead box protein N2
DEG_SCF_TRCP1_1
364:369
DSGYAS
BTRC
0.9941
More...