DegronMD - Q9H3R0(KDM4C)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A376S	TCGA-50-5049	LUAD	TCGA	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7588
p.A376S	DO23705	LUAD	ICGC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7588
p.A546V	TCGA-63-A5MM	LUSC	TCGA	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.1944
p.A546V	DO219153	LUSC	ICGC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.1944
p.K381I	TCGA-78-8662	LUAD	TCGA	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.3056
p.K381I	DO45346	LUAD	ICGC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.3056
p.T379I	TCGA-B5-A11E	UCEC	TCGA	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7078
p.T379I	DO41644	UCEC	ICGC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7078
p.G542V	TCGA-BF-A1PU	SKCM	TCGA	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.0833
p.G542V	DO50278	SKCM	ICGC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.0833
p.V547L	TCGA-CC-A7IF	LIHC	TCGA	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.2222
p.V547L	DO52177	LIHC	ICGC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.2222
p.E387D	TCGA-CR-7402	HNSC	TCGA	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1389
p.E387D	DO15727	HNSC	ICGC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1389
p.P348L	TCGA-DD-A1EB	LIHC	TCGA	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.6471
p.P348L	DO22836	LIHC	ICGC	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.6471
p.R382S	TCGA-DX-A6YS	SARC	TCGA	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.2778
p.R382S	DO220005	SARC	ICGC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.2778
p.K338N	TCGA-E2-A15A	BRCA	TCGA	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation blocking ubiquitination signal	0.5
p.K338N	DO1357	BRCA	ICGC	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation blocking ubiquitination signal	0.5
p.R377M	TCGA-ER-A19P	SKCM	TCGA	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7521
p.R377M	DO47623	SKCM	ICGC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7521
p.S370F	TCGA-FR-A8YC	SKCM	TCGA	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1667
p.S370F	DO50301	SKCM	ICGC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1667
p.P383H	TCGA-G4-6588	COAD	TCGA	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.25
p.P383H	DO10140	COAD	ICGC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.25
p.V562I	DO51928	BLCA	ICGC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.2778
p.R371Q	DO222884	COCA	ICGC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1944
p.P558L	DO233653	GACA	ICGC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation altering degron motif	0.7582
p.G567R	DO228944	LICA	ICGC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.1389
p.S549N	DO228947	LICA	ICGC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.2778
p.S549N	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.2778
p.S549N	SIDM00687	Gastric Carcinoma	GDSC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.2778
p.S549N	SIDM00410	Other Blood Cancers	GDSC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.2778
p.S549N	SIDM00363	Acute Myeloid Leukemia	GDSC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.2778
p.S549N	SIDM01444	Glioblastoma	GDSC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.2778
p.A351S	DO228952	LICA	ICGC	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.6477
p.W359C	DO229034	LICA	ICGC	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.1667
p.A568S	DO229045	LICA	ICGC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.1111
p.C558Y	DO48559	LIHC	ICGC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation altering degron motif	0.7087
p.C558G	DO48559	LIHC	ICGC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation altering degron motif	0.76
p.S566P	DO43154	UCEC	ICGC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation substituting flanking lysine	0.2778
p.T349I	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.7078
p.T349I	ACH-000226	Lymphoma	CCLE	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.7078
p.T349I	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation altering degron motif	0.7078
p.A369S	SIDM00336	Melanoma	GDSC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1389
p.A369S	ACH-000881	Skin Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1389
p.A369S	MEL-JUSO	skin	COSMIC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1389
p.Y341C	SIDM00466	Ovarian Carcinoma	GDSC	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.1389
p.Y341C	ACH-000443	Ovarian Cancer	CCLE	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.1389
p.Y341C	OVKATE	ovary	COSMIC	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.1389
p.F373L	SIDM01196	Hepatocellular Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.25
p.F373L	SIDM01564	Colorectal Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.25
p.F373L	SNU-475	liver	COSMIC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.25
p.A376V	SIDM01146	Gastric Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.5825
p.A376V	ACH-000932	Gastric Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.5825
p.A376V	NCI-SNU-1	stomach	COSMIC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.5825
p.D344E	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.2222
p.D344E	ACH-000727	Lung Cancer	CCLE	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.2222
p.D344E	NCI-H2066	lung	COSMIC	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.2222
p.R552K	ACH-000937	Leukemia	CCLE	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation altering degron motif	0.6126
p.P340R	HCC-15	lung	COSMIC	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.1111
p.E563K	IGROV-1	ovary	COSMIC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.25
p.E550K	NCI-H1792	lung	COSMIC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.3056
p.V363I	MRK-nu-1	breast	COSMIC	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.0556
p.D366E	NCI-H2066	lung	COSMIC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0556
p.A561T	STS-0421	soft tissue	COSMIC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.3056
p.S567C	HAL-01	haematopoietic and lymphoid tissue	COSMIC	ERNSFKVPSI	DEG_COP1_1	551:560	Mutation rewiring degron network	0.1389
p.T371I	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	ARSTS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1944
p.Y363C	OVKATE	ovary	COSMIC	PTPAST	DEG_SCF_FBW7_1	348:353	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KDM4C

UniProt ID: Q9H3R0

Entrez ID: 23081

Protein name: Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KDM4C in