DegronMD

Uniprot ID: Q9H3R0

Source protein: Lysine-specific demethylase 4C

Source gene: KDM4C

Class: DEG_SCF_FBW7_1

Location: 348:353

E3 ligase: FBXW7

DEGRON score: 0.7579

ASA_SCORE: 71.3667

COIL: 0.956

CONS_SCORE: 0.3642

DSS_SCORE: 0.4822

HELIX: 0.0225

FCONS_SCORE: 1.1215

RIG_SCORE: 0.6883

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P348L	TCGA-DD-A1EB	LIHC	TCGA	PTPAST	DEG_SCF_FBW7_1	0.6471
p.P348L	DO22836	LIHC	ICGC	PTPAST	DEG_SCF_FBW7_1	0.6471
p.K338N	TCGA-E2-A15A	BRCA	TCGA	PTPAST	DEG_SCF_FBW7_1	0.5
p.K338N	DO1357	BRCA	ICGC	PTPAST	DEG_SCF_FBW7_1	0.5
p.A351S	DO228952	LICA	ICGC	PTPAST	DEG_SCF_FBW7_1	0.6477
p.W359C	DO229034	LICA	ICGC	PTPAST	DEG_SCF_FBW7_1	0.1667
p.T349I	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	PTPAST	DEG_SCF_FBW7_1	0.7078
p.T349I	ACH-000226	Lymphoma	CCLE	PTPAST	DEG_SCF_FBW7_1	0.7078
p.T349I	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	PTPAST	DEG_SCF_FBW7_1	0.7078
p.Y341C	SIDM00466	Ovarian Carcinoma	GDSC	PTPAST	DEG_SCF_FBW7_1	0.1389
p.Y341C	ACH-000443	Ovarian Cancer	CCLE	PTPAST	DEG_SCF_FBW7_1	0.1389
p.Y341C	OVKATE	ovary	COSMIC	PTPAST	DEG_SCF_FBW7_1	0.1389
p.D344E	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	PTPAST	DEG_SCF_FBW7_1	0.2222
p.D344E	ACH-000727	Lung Cancer	CCLE	PTPAST	DEG_SCF_FBW7_1	0.2222
p.D344E	NCI-H2066	lung	COSMIC	PTPAST	DEG_SCF_FBW7_1	0.2222
p.P340R	HCC-15	lung	COSMIC	PTPAST	DEG_SCF_FBW7_1	0.1111
p.V363I	MRK-nu-1	breast	COSMIC	PTPAST	DEG_SCF_FBW7_1	0.0556
p.Y363C	OVKATE	ovary	COSMIC	PTPAST	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H3R0	Lysine-specific demethylase 4C	DEG_SCF_FBW7_1	348:353	PTPAST	FBXW7	0.7579	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons