DegronMD

Uniprot ID: Q9H3R0

Source protein: Lysine-specific demethylase 4C

Source gene: KDM4C

Class: DEG_COP1_1

Location: 551:560

E3 ligase: COP1

DEGRON score: 0.6887

ASA_SCORE: 91.64

COIL: 0.8172

CONS_SCORE: 0.3011

DSS_SCORE: 0.624

HELIX: 0.0537

FCONS_SCORE: 1.0071

RIG_SCORE: 0.6746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A546V	TCGA-63-A5MM	LUSC	TCGA	ERNSFKVPSI	DEG_COP1_1	0.1944
p.A546V	DO219153	LUSC	ICGC	ERNSFKVPSI	DEG_COP1_1	0.1944
p.G542V	TCGA-BF-A1PU	SKCM	TCGA	ERNSFKVPSI	DEG_COP1_1	0.0833
p.G542V	DO50278	SKCM	ICGC	ERNSFKVPSI	DEG_COP1_1	0.0833
p.V547L	TCGA-CC-A7IF	LIHC	TCGA	ERNSFKVPSI	DEG_COP1_1	0.2222
p.V547L	DO52177	LIHC	ICGC	ERNSFKVPSI	DEG_COP1_1	0.2222
p.V562I	DO51928	BLCA	ICGC	ERNSFKVPSI	DEG_COP1_1	0.2778
p.P558L	DO233653	GACA	ICGC	ERNSFKVPSI	DEG_COP1_1	0.7582
p.G567R	DO228944	LICA	ICGC	ERNSFKVPSI	DEG_COP1_1	0.1389
p.S549N	DO228947	LICA	ICGC	ERNSFKVPSI	DEG_COP1_1	0.2778
p.S549N	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	ERNSFKVPSI	DEG_COP1_1	0.2778
p.S549N	SIDM00687	Gastric Carcinoma	GDSC	ERNSFKVPSI	DEG_COP1_1	0.2778
p.S549N	SIDM00410	Other Blood Cancers	GDSC	ERNSFKVPSI	DEG_COP1_1	0.2778
p.S549N	SIDM00363	Acute Myeloid Leukemia	GDSC	ERNSFKVPSI	DEG_COP1_1	0.2778
p.S549N	SIDM01444	Glioblastoma	GDSC	ERNSFKVPSI	DEG_COP1_1	0.2778
p.A568S	DO229045	LICA	ICGC	ERNSFKVPSI	DEG_COP1_1	0.1111
p.C558Y	DO48559	LIHC	ICGC	ERNSFKVPSI	DEG_COP1_1	0.7087
p.C558G	DO48559	LIHC	ICGC	ERNSFKVPSI	DEG_COP1_1	0.76
p.S566P	DO43154	UCEC	ICGC	ERNSFKVPSI	DEG_COP1_1	0.2778
p.R552K	ACH-000937	Leukemia	CCLE	ERNSFKVPSI	DEG_COP1_1	0.6126
p.E563K	IGROV-1	ovary	COSMIC	ERNSFKVPSI	DEG_COP1_1	0.25
p.E550K	NCI-H1792	lung	COSMIC	ERNSFKVPSI	DEG_COP1_1	0.3056
p.A561T	STS-0421	soft_tissue	COSMIC	ERNSFKVPSI	DEG_COP1_1	0.3056
p.S567C	HAL-01	haematopoietic_and_lymphoid_tissue	COSMIC	ERNSFKVPSI	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H3R0	Lysine-specific demethylase 4C	DEG_COP1_1	551:560	ERNSFKVPSI	COP1	0.6887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons