DegronMD

Uniprot ID: Q9BXK1

Source protein: Krueppel-like factor 16

Source gene: KLF16

Class: DEG_SPOP_SBC_1

Location: 222:226

E3 ligase: SPOP

DEGRON score: 0.9312

ASA_SCORE: 85.6

COIL: 0.888

CONS_SCORE: 0.133

DSS_SCORE: 0.6381

HELIX: 0.0314

FCONS_SCORE: 0.753

RIG_SCORE: 0.5309

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R223C	DO230309	COCA	ICGC	ARSTS	DEG_SPOP_SBC_1	0.719
p.T225A	DO228123	EOPC	ICGC	ARSTS	DEG_SPOP_SBC_1	0.7139
p.L216M	DO229027	LICA	ICGC	ARSTS	DEG_SPOP_SBC_1	0.1667
p.L216M	DO229211	THCA	ICGC	ARSTS	DEG_SPOP_SBC_1	0.1667
p.D229V	DO229218	THCA	ICGC	ARSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00409	Forkhead box protein N3	DEG_SPOP_SBC_1	345:349	ARSTS	SPOP	0.9829	More...
O14874	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	DEG_SPOP_SBC_1	29:33	ARSTS	SPOP	0.999	More...
Q6ZSM3	Monocarboxylate transporter 12	DEG_SPOP_SBC_1	37:41	ARSTS	SPOP	0.6242	More...
Q9H3R0	Lysine-specific demethylase 4C	DEG_SPOP_SBC_1	376:380	ARSTS	SPOP	0.9041	More...
Q9BXK1	Krueppel-like factor 16	DEG_SPOP_SBC_1	222:226	ARSTS	SPOP	0.9312	More...
Q8NET4	Retrotransposon Gag-like protein 9	DEG_SPOP_SBC_1	1026:1030	ARSTS	SPOP	0.702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons