DegronMD - O14874(BCKDK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A34S	TCGA-AR-A251	BRCA	TCGA	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.3056
p.A34S	DO5724	BRCA	ICGC	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.3056
p.R30C	TCGA-CK-5913	COAD	TCGA	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.719
p.R30C	DO8826	COAD	ICGC	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.719
p.P23S	TCGA-CV-7568	HNSC	TCGA	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1667
p.P23S	DO14160	HNSC	ICGC	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1667
p.A24T	TCGA-FI-A2D5	UCEC	TCGA	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1944
p.A24T	TCGA-FS-A1ZT	SKCM	TCGA	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1944
p.A24T	DO37468	SKCM	ICGC	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1944
p.A24T	DO41331	UCEC	ICGC	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1944
p.A26V	TCGA-VQ-A8PT	STAD	TCGA	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.25
p.A26V	DO233867	GACA	ICGC	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.25
p.A26V	DO51776	STAD	ICGC	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.25
p.L21R	DO234404	ESAD	ICGC	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1111
p.A24S	DO229037	LICA	ICGC	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1944
p.V40M	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1389
p.V40M	ACH-000924	Lung Cancer	CCLE	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1389
p.R30H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7133
p.R30H	ACH-002256	Leukemia	CCLE	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7133
p.R30H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ARSTS	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.7133

Kaplan plot for BCKDK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BCKDK

UniProt ID: O14874

Entrez ID: 10295

Protein name: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial (EC 2.7.11.4) (Branched-chain alpha-ketoacid dehydrogenase kinase) (BCKD-kinase) (BCKDHKIN)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BCKDK in