DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PLMTPKAS
Uniprot ID:
Q8NET4
Source protein:
Retrotransposon Gag-like protein 9
Source gene:
RTL9
Class:
DEG_SCF_FBW7_1
Location:
617:624
E3 ligase:
FBXW7
DEGRON score:
0.9227
ASA_SCORE:
94.5125
COIL:
0.895
CONS_SCORE:
0.4423
DSS_SCORE:
0.4867
HELIX:
0.0334
FCONS_SCORE:
0.985
RIG_SCORE:
0.6769
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.M619T
SIDM00574
Glioblastoma
GDSC
PLMTPKAS
DEG_SCF_FBW7_1
0.6312
p.M619T
no-10
central_nervous_system
COSMIC
PLMTPKAS
DEG_SCF_FBW7_1
0.6312
Drug responses associated with RTL9 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PLMTPKAS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NET4
Retrotransposon Gag-like protein 9
DEG_SCF_FBW7_1
617:624
PLMTPKAS
FBXW7
0.9227
More...