DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DSGTLS
Uniprot ID:
Q8NET4
Source protein:
Retrotransposon Gag-like protein 9
Source gene:
RTL9
Class:
DEG_SCF_TRCP1_1
Location:
122:127
E3 ligase:
BTRC
DEGRON score:
0.9784
ASA_SCORE:
77.95
COIL:
0.8895
CONS_SCORE:
0.373
DSS_SCORE:
0.3
HELIX:
0.0333
FCONS_SCORE:
1.0846
RIG_SCORE:
0.6997
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S131P
SIDM00217
Colorectal Carcinoma
GDSC
DSGTLS
DEG_SCF_TRCP1_1
0.2222
p.S131P
SNU-1040
large_intestine
COSMIC
DSGTLS
DEG_SCF_TRCP1_1
0.2222
Drug responses associated with RTL9 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGTLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NET4
Retrotransposon Gag-like protein 9
DEG_SCF_TRCP1_1
122:127
DSGTLS
BTRC
0.9784
More...