DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGEAST
Uniprot ID:
Q8NET4
Source protein:
Retrotransposon Gag-like protein 9
Source gene:
RTL9
Class:
DEG_SCF_TRCP1_1
Location:
1101:1107
E3 ligase:
BTRC
DEGRON score:
0.969
ASA_SCORE:
86.7714
COIL:
0.9134
CONS_SCORE:
0.5104
DSS_SCORE:
0.6295
HELIX:
0.0406
FCONS_SCORE:
1.0586
RIG_SCORE:
0.6389
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1108A
SIDM01619
Endometrial Carcinoma
GDSC
DSGEAST
DEG_SCF_TRCP1_1
0.3056
Drug responses associated with RTL9 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGEAST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NET4
Retrotransposon Gag-like protein 9
DEG_SCF_TRCP1_1
1101:1107
DSGEAST
BTRC
0.969
More...