DegronMD - A1KXE4(FAM168B)

GO - Biological processes (BP): View more >>

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y180H	TCGA-B5-A3FA	UCEC	TCGA	PGTPTYS	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.25
p.Y180H	DO52402	UCEC	ICGC	PGTPTYS	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.25
p.R181Q	TCGA-BH-A1EX	BRCA	TCGA	PGTPTYS	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.2778
p.R181Q	DO4257	BRCA	ICGC	PGTPTYS	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.2778
p.Y180C	TCGA-DI-A1BU	UCEC	TCGA	PGTPTYS	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.25
p.Y180C	DO42023	UCEC	ICGC	PGTPTYS	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.25
p.P192H	DO229036	LICA	ICGC	PGTPTYS	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.25
p.T187N	ACH-000167	Myeloma	CCLE	PGTPTYS	DEG_SCF_FBW7_1	183:189	Mutation altering degron motif	0.5944
p.Y190C	ACH-000269	Brain Cancer	CCLE	PGTPTYS	DEG_SCF_FBW7_1	183:189	Mutation blocking phosphorylation signal	0.75

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons