DegronMD

Uniprot ID: A1KXE4

Source protein: Myelin-associated neurite-outgrowth inhibitor

Source gene: FAM168B

Class: DEG_SCF_FBW7_1

Location: 183:189

E3 ligase: FBXW7

DEGRON score: 0.995

ASA_SCORE: 73

COIL: 0.8661

CONS_SCORE: 0.9404

DSS_SCORE: 0.4342

HELIX: 0.0207

FCONS_SCORE: 1.0174

RIG_SCORE: 0.6911

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y180H	TCGA-B5-A3FA	UCEC	TCGA	PGTPTYS	DEG_SCF_FBW7_1	0.25
p.Y180H	DO52402	UCEC	ICGC	PGTPTYS	DEG_SCF_FBW7_1	0.25
p.R181Q	TCGA-BH-A1EX	BRCA	TCGA	PGTPTYS	DEG_SCF_FBW7_1	0.2778
p.R181Q	DO4257	BRCA	ICGC	PGTPTYS	DEG_SCF_FBW7_1	0.2778
p.Y180C	TCGA-DI-A1BU	UCEC	TCGA	PGTPTYS	DEG_SCF_FBW7_1	0.25
p.Y180C	DO42023	UCEC	ICGC	PGTPTYS	DEG_SCF_FBW7_1	0.25
p.P192H	DO229036	LICA	ICGC	PGTPTYS	DEG_SCF_FBW7_1	0.25
p.T187N	ACH-000167	Myeloma	CCLE	PGTPTYS	DEG_SCF_FBW7_1	0.5944
p.Y190C	ACH-000269	Brain Cancer	CCLE	PGTPTYS	DEG_SCF_FBW7_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1KXE4	Myelin-associated neurite-outgrowth inhibitor	DEG_SCF_FBW7_1	183:189	PGTPTYS	FBXW7	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons