DegronMD - A2A3K4(PTPDC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M26I	TCGA-17-Z056	LUAD	TCGA	PTPKYT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.1389
p.M26I	DO225046	BRCA	ICGC	PTPKYT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.1389
p.R33W	TCGA-IB-7651	PAAD	TCGA	PTPKYT	DEG_SCF_FBW7_1	33:38	Mutation altering degron motif	0.8634
p.R33W	DO46657	PAAD	ICGC	PTPKYT	DEG_SCF_FBW7_1	33:38	Mutation altering degron motif	0.8634
p.R24W	DO225094	BRCA	ICGC	PTPKYT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.0833
p.G46V	DO225277	BRCA	ICGC	PTPKYT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.1111
p.Q36L	DO228234	LICA	ICGC	PTPKYT	DEG_SCF_FBW7_1	33:38	Mutation altering degron motif	0.7765
p.R33L	DO23186	LINC	ICGC	PTPKYT	DEG_SCF_FBW7_1	33:38	Mutation altering degron motif	0.8428
p.R39W	SIDM02021	Esophageal Carcinoma	GDSC	PTPKYT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.3056
p.R39W	SIDM00359	Colorectal Carcinoma	GDSC	PTPKYT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.3056
p.R39W	ACH-000565	Colon/Colorectal Cancer	CCLE	PTPKYT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.3056
p.R39W	RCM-1	large intestine	COSMIC	PTPKYT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.3056
p.R38Q	SIDM01048	Plasma Cell Myeloma	GDSC	PTPKYT	DEG_SCF_FBW7_1	33:38	Mutation altering degron motif	0.7329
p.R45Q	SNU-1040	large intestine	COSMIC	PTPKYT	DEG_SCF_FBW7_1	33:38	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons