DegronMD

Uniprot ID: A2A3K4

Source protein: Protein tyrosine phosphatase domain-containing protein 1

Source gene: PTPDC1

Class: DEG_SCF_FBW7_1

Location: 33:38

E3 ligase: FBXW7

DEGRON score: 0.687

ASA_SCORE: 48.45

COIL: 0.7772

CONS_SCORE: 0.3321

DSS_SCORE: 0.4942

HELIX: 0.15

FCONS_SCORE: 1.2054

RIG_SCORE: 0.7623

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M26I	TCGA-17-Z056	LUAD	TCGA	PTPKYT	DEG_SCF_FBW7_1	0.1389
p.M26I	DO225046	BRCA	ICGC	PTPKYT	DEG_SCF_FBW7_1	0.1389
p.R33W	TCGA-IB-7651	PAAD	TCGA	PTPKYT	DEG_SCF_FBW7_1	0.8634
p.R33W	DO46657	PAAD	ICGC	PTPKYT	DEG_SCF_FBW7_1	0.8634
p.R24W	DO225094	BRCA	ICGC	PTPKYT	DEG_SCF_FBW7_1	0.0833
p.G46V	DO225277	BRCA	ICGC	PTPKYT	DEG_SCF_FBW7_1	0.1111
p.Q36L	DO228234	LICA	ICGC	PTPKYT	DEG_SCF_FBW7_1	0.7765
p.R33L	DO23186	LINC	ICGC	PTPKYT	DEG_SCF_FBW7_1	0.8428
p.R39W	SIDM02021	Esophageal Carcinoma	GDSC	PTPKYT	DEG_SCF_FBW7_1	0.3056
p.R39W	SIDM00359	Colorectal Carcinoma	GDSC	PTPKYT	DEG_SCF_FBW7_1	0.3056
p.R39W	ACH-000565	Colon/Colorectal Cancer	CCLE	PTPKYT	DEG_SCF_FBW7_1	0.3056
p.R39W	RCM-1	large_intestine	COSMIC	PTPKYT	DEG_SCF_FBW7_1	0.3056
p.R38Q	SIDM01048	Plasma Cell Myeloma	GDSC	PTPKYT	DEG_SCF_FBW7_1	0.7329
p.R45Q	SNU-1040	large_intestine	COSMIC	PTPKYT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2A3K4	Protein tyrosine phosphatase domain-containing protein 1	DEG_SCF_FBW7_1	33:38	PTPKYT	FBXW7	0.687	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons