DegronMD - A2RRP1(NBAS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R694Q	TCGA-06-5416	GBM	TCGA	RRKLLTYLD	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.3056
p.R694Q	DO10880	GBM	ICGC	RRKLLTYLD	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.3056
p.C682W	TCGA-44-7660	LUAD	TCGA	RRKLLTYLD	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.25
p.C682W	DO23834	LUAD	ICGC	RRKLLTYLD	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.25
p.R683C	TCGA-94-7033	LUSC	TCGA	RRKLLTYLD	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.2778
p.R683C	DO26498	LUSC	ICGC	RRKLLTYLD	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.2778
p.G703A	SIDM00454	Rhabdomyosarcoma	GDSC	RRKLLTYLD	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.0556
p.G703A	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	RRKLLTYLD	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.0556
p.G703A	SIDM00971	Breast Carcinoma	GDSC	RRKLLTYLD	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.0556
p.G703A	SIDM00257	Neuroblastoma	GDSC	RRKLLTYLD	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.0556
p.R686Q	SIDM00217	Colorectal Carcinoma	GDSC	RRKLLTYLD	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.7329
p.R686Q	ACH-000999	Colon/Colorectal Cancer	CCLE	RRKLLTYLD	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.7329
p.R686Q	SNU-1040	large intestine	COSMIC	RRKLLTYLD	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.7329
p.C682Y	SIDM00500	Colorectal Carcinoma	GDSC	RRKLLTYLD	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.25
p.C682Y	ACH-000959	Colon/Colorectal Cancer	CCLE	RRKLLTYLD	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.25

Kaplan plot for NBAS in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NBAS

UniProt ID: A2RRP1

Entrez ID: 51594

Protein name: NBAS subunit of NRZ tethering complex (Neuroblastoma-amplified gene protein) (Neuroblastoma-amplified sequence)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NBAS in