DegronMD

Uniprot ID: A2RRP1

Source protein: NBAS subunit of NRZ tethering complex

Source gene: NBAS

Class: DEG_APCC_DBOX_1

Location: 685:693

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6867

ASA_SCORE: 52.5667

COIL: 0.1162

CONS_SCORE: 0.5551

DSS_SCORE: 0.0325

HELIX: 0.8826

FCONS_SCORE: 1.2197

RIG_SCORE: 0.93

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R694Q	TCGA-06-5416	GBM	TCGA	RRKLLTYLD	DEG_APCC_DBOX_1	0.3056
p.R694Q	DO10880	GBM	ICGC	RRKLLTYLD	DEG_APCC_DBOX_1	0.3056
p.C682W	TCGA-44-7660	LUAD	TCGA	RRKLLTYLD	DEG_APCC_DBOX_1	0.25
p.C682W	DO23834	LUAD	ICGC	RRKLLTYLD	DEG_APCC_DBOX_1	0.25
p.R683C	TCGA-94-7033	LUSC	TCGA	RRKLLTYLD	DEG_APCC_DBOX_1	0.2778
p.R683C	DO26498	LUSC	ICGC	RRKLLTYLD	DEG_APCC_DBOX_1	0.2778
p.G703A	SIDM00454	Rhabdomyosarcoma	GDSC	RRKLLTYLD	DEG_APCC_DBOX_1	0.0556
p.G703A	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	RRKLLTYLD	DEG_APCC_DBOX_1	0.0556
p.G703A	SIDM00971	Breast Carcinoma	GDSC	RRKLLTYLD	DEG_APCC_DBOX_1	0.0556
p.G703A	SIDM00257	Neuroblastoma	GDSC	RRKLLTYLD	DEG_APCC_DBOX_1	0.0556
p.R686Q	SIDM00217	Colorectal Carcinoma	GDSC	RRKLLTYLD	DEG_APCC_DBOX_1	0.7329
p.R686Q	ACH-000999	Colon/Colorectal Cancer	CCLE	RRKLLTYLD	DEG_APCC_DBOX_1	0.7329
p.R686Q	SNU-1040	large_intestine	COSMIC	RRKLLTYLD	DEG_APCC_DBOX_1	0.7329
p.C682Y	SIDM00500	Colorectal Carcinoma	GDSC	RRKLLTYLD	DEG_APCC_DBOX_1	0.25
p.C682Y	ACH-000959	Colon/Colorectal Cancer	CCLE	RRKLLTYLD	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RRP1	NBAS subunit of NRZ tethering complex	DEG_APCC_DBOX_1	685:693	RRKLLTYLD	APC,CDC20,FZR1	0.6867	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons