DegronMD - A2RUS2(DENND3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N375K	TCGA-19-5956	GBM	TCGA	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.25
p.N375K	DO13863	GBM	ICGC	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.25
p.T361I	TCGA-2W-A8YY	CESC	TCGA	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation blocking phosphorylation signal	0.6111
p.T361I	DO223732	CESC	ICGC	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation blocking phosphorylation signal	0.6111
p.R371M	TCGA-D3-A2JO	SKCM	TCGA	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.7521
p.R371M	DO47619	SKCM	ICGC	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.7521
p.E380K	TCGA-EE-A29M	SKCM	TCGA	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1111
p.E380K	DO37404	SKCM	ICGC	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1111
p.K374T	TCGA-EY-A215	UCEC	TCGA	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation blocking ubiquitination signal	0.7222
p.K374T	DO42665	UCEC	ICGC	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation blocking ubiquitination signal	0.7222
p.K374N	DO8264	COAD	ICGC	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation blocking ubiquitination signal	0.7222
p.V373L	DO228974	LICA	ICGC	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.3056
p.D372Y	DO228974	LICA	ICGC	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.7325
p.L363P	DO229048	LICA	ICGC	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.2222
p.E380D	SIDM02044	Colorectal Carcinoma	GDSC	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1111
p.G362S	SIDM00660	Colorectal Carcinoma	GDSC	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1944
p.G362S	ACH-000985	Colon/Colorectal Cancer	CCLE	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1944
p.G362S	LS-411N	large intestine	COSMIC	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1944
p.E359D	SIDM01442	Glioma	GDSC	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1111
p.E359D	ACH-000807	Brain Cancer	CCLE	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1111
p.Q381H	STS-0421	soft tissue	COSMIC	VSIFRD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.0833

Kaplan plot for DENND3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DENND3

UniProt ID: A2RUS2

Entrez ID: 22898

Protein name: DENN domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DENND3 in