DegronMD

Uniprot ID: A2RUS2

Source protein: DENN domain-containing protein 3

Source gene: DENND3

Class: LIG_APCC_ABBA_1

Location: 367:372

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5978

ASA_SCORE: 24.3333

COIL: 0.0893

CONS_SCORE: 0.5533

DSS_SCORE: 0.0905

HELIX: 0.9067

FCONS_SCORE: 1.2541

RIG_SCORE: 0.8963

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N375K	TCGA-19-5956	GBM	TCGA	VSIFRD	LIG_APCC_ABBA_1	0.25
p.N375K	DO13863	GBM	ICGC	VSIFRD	LIG_APCC_ABBA_1	0.25
p.T361I	TCGA-2W-A8YY	CESC	TCGA	VSIFRD	LIG_APCC_ABBA_1	0.6111
p.T361I	DO223732	CESC	ICGC	VSIFRD	LIG_APCC_ABBA_1	0.6111
p.R371M	TCGA-D3-A2JO	SKCM	TCGA	VSIFRD	LIG_APCC_ABBA_1	0.7521
p.R371M	DO47619	SKCM	ICGC	VSIFRD	LIG_APCC_ABBA_1	0.7521
p.E380K	TCGA-EE-A29M	SKCM	TCGA	VSIFRD	LIG_APCC_ABBA_1	0.1111
p.E380K	DO37404	SKCM	ICGC	VSIFRD	LIG_APCC_ABBA_1	0.1111
p.K374T	TCGA-EY-A215	UCEC	TCGA	VSIFRD	LIG_APCC_ABBA_1	0.7222
p.K374T	DO42665	UCEC	ICGC	VSIFRD	LIG_APCC_ABBA_1	0.7222
p.K374N	DO8264	COAD	ICGC	VSIFRD	LIG_APCC_ABBA_1	0.7222
p.V373L	DO228974	LICA	ICGC	VSIFRD	LIG_APCC_ABBA_1	0.3056
p.D372Y	DO228974	LICA	ICGC	VSIFRD	LIG_APCC_ABBA_1	0.7325
p.L363P	DO229048	LICA	ICGC	VSIFRD	LIG_APCC_ABBA_1	0.2222
p.E380D	SIDM02044	Colorectal Carcinoma	GDSC	VSIFRD	LIG_APCC_ABBA_1	0.1111
p.G362S	SIDM00660	Colorectal Carcinoma	GDSC	VSIFRD	LIG_APCC_ABBA_1	0.1944
p.G362S	ACH-000985	Colon/Colorectal Cancer	CCLE	VSIFRD	LIG_APCC_ABBA_1	0.1944
p.G362S	LS-411N	large_intestine	COSMIC	VSIFRD	LIG_APCC_ABBA_1	0.1944
p.E359D	SIDM01442	Glioma	GDSC	VSIFRD	LIG_APCC_ABBA_1	0.1111
p.E359D	ACH-000807	Brain Cancer	CCLE	VSIFRD	LIG_APCC_ABBA_1	0.1111
p.Q381H	STS-0421	soft_tissue	COSMIC	VSIFRD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RUS2	DENN domain-containing protein 3	LIG_APCC_ABBA_1	367:372	VSIFRD	APC,CDC20,FZR1	0.5978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons