DegronMD - A4D1E1(ZNF804B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A986G	TCGA-13-2065	OV	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1389
p.A986G	DO30560	OV	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1389
p.P962S	TCGA-21-5787	LUSC	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1944
p.P962S	DO26605	LUSC	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1944
p.P962L	TCGA-50-6590	LUAD	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1944
p.P962L	TCGA-KR-A7K0	LIHC	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1944
p.P962L	DO49696	LIHC	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1944
p.P962L	DO24692	LUAD	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1944
p.V961F	TCGA-55-7995	LUAD	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1667
p.V961F	DO45323	LUAD	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1667
p.Q984H	TCGA-AP-A0L9	UCEC	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1944
p.Q984H	DO40948	UCEC	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1944
p.G971S	TCGA-BF-A1Q0	SKCM	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.5882
p.G971S	DO47374	SKCM	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.5882
p.G971V	TCGA-BR-A4PD	STAD	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.6421
p.G971V	DO47831	STAD	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.6421
p.I983M	TCGA-CA-6718	COAD	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.2222
p.I983M	DO7801	COAD	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.2222
p.A986T	TCGA-CG-4305	STAD	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1389
p.A986T	DO38823	STAD	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1389
p.R974K	TCGA-EW-A1J5	BRCA	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.6126
p.R974K	DO6144	BRCA	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.6126
p.E988K	TCGA-FW-A3R5	SKCM	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.0833
p.E988K	DO37406	SKCM	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.0833
p.P962R	TCGA-V5-A7RC	ESCA	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1944
p.A976T	TCGA-VQ-A8PT	STAD	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.6028
p.A976T	DO228338	MALY	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.6028
p.A976T	DO34480	PACA	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.6028
p.A976T	DO51776	STAD	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.6028
p.A976T	SIDM00282	Colorectal Carcinoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.6028
p.A976T	SIDM00948	Burkitt's Lymphoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.6028
p.A976T	ACH-000998	Colon/Colorectal Cancer	CCLE	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.6028
p.A976T	ACH-002232	Lymphoma	CCLE	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.6028
p.A976T	DG-75	haematopoietic and lymphoid tissue	COSMIC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.6028
p.S987R	DO233064	GACA	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1111
p.S959L	DO36556	READ	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1111
p.S959L	ACH-002061	Leukemia	CCLE	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.1111
p.I965V	SIDM00633	Breast Carcinoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.2778
p.I965V	SIDM01097	Other Solid Cancers	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.2778
p.I965V	SIDM00971	Breast Carcinoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.2778
p.I965V	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.2778
p.I965V	SIDM01387	Small Cell Lung Carcinoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.2778
p.T964A	SIDM00694	Other Solid Cancers	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.25
p.T964A	SIDM00878	Breast Carcinoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.25
p.T964A	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.25
p.T964A	SIDM00863	Burkitt's Lymphoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.25
p.T964A	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.25
p.T964A	SIDM01752	Pancreatic Carcinoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation rewiring degron network	0.25
p.A976E	ACH-001111	Lymphoma	CCLE	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.659
p.P971S	RVH-421	skin	COSMIC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	967:979	Mutation altering degron motif	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF804B

UniProt ID: A4D1E1

Entrez ID: 219578

Protein name: Zinc finger protein 804B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF804B in