DegronMD

Uniprot ID: A4D1E1

Source protein: Zinc finger protein 804B

Source gene: ZNF804B

Class: DEG_ODPH_VHL_1

Location: 967:979

E3 ligase: VHL

DEGRON score: 0.9734

ASA_SCORE: 69.1462

COIL: 0.7512

CONS_SCORE: 0.3793

DSS_SCORE: 0.3805

HELIX: 0.1274

FCONS_SCORE: 0.9409

RIG_SCORE: 0.7286

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A986G	TCGA-13-2065	OV	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1389
p.A986G	DO30560	OV	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1389
p.P962S	TCGA-21-5787	LUSC	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1944
p.P962S	DO26605	LUSC	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1944
p.P962L	TCGA-50-6590	LUAD	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1944
p.P962L	TCGA-KR-A7K0	LIHC	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1944
p.P962L	DO49696	LIHC	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1944
p.P962L	DO24692	LUAD	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1944
p.V961F	TCGA-55-7995	LUAD	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1667
p.V961F	DO45323	LUAD	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1667
p.Q984H	TCGA-AP-A0L9	UCEC	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1944
p.Q984H	DO40948	UCEC	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1944
p.G971S	TCGA-BF-A1Q0	SKCM	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.5882
p.G971S	DO47374	SKCM	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.5882
p.G971V	TCGA-BR-A4PD	STAD	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.6421
p.G971V	DO47831	STAD	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.6421
p.I983M	TCGA-CA-6718	COAD	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.2222
p.I983M	DO7801	COAD	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.2222
p.A986T	TCGA-CG-4305	STAD	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1389
p.A986T	DO38823	STAD	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1389
p.R974K	TCGA-EW-A1J5	BRCA	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.6126
p.R974K	DO6144	BRCA	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.6126
p.E988K	TCGA-FW-A3R5	SKCM	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.0833
p.E988K	DO37406	SKCM	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.0833
p.P962R	TCGA-V5-A7RC	ESCA	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1944
p.A976T	TCGA-VQ-A8PT	STAD	TCGA	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.6028
p.A976T	DO228338	MALY	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.6028
p.A976T	DO34480	PACA	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.6028
p.A976T	DO51776	STAD	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.6028
p.A976T	SIDM00282	Colorectal Carcinoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.6028
p.A976T	SIDM00948	Burkitt's Lymphoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.6028
p.A976T	ACH-000998	Colon/Colorectal Cancer	CCLE	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.6028
p.A976T	ACH-002232	Lymphoma	CCLE	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.6028
p.A976T	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.6028
p.S987R	DO233064	GACA	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1111
p.S959L	DO36556	READ	ICGC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1111
p.S959L	ACH-002061	Leukemia	CCLE	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.1111
p.I965V	SIDM00633	Breast Carcinoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.2778
p.I965V	SIDM01097	Other Solid Cancers	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.2778
p.I965V	SIDM00971	Breast Carcinoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.2778
p.I965V	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.2778
p.I965V	SIDM01387	Small Cell Lung Carcinoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.2778
p.T964A	SIDM00694	Other Solid Cancers	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.25
p.T964A	SIDM00878	Breast Carcinoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.25
p.T964A	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.25
p.T964A	SIDM00863	Burkitt's Lymphoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.25
p.T964A	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.25
p.T964A	SIDM01752	Pancreatic Carcinoma	GDSC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.25
p.A976E	ACH-001111	Lymphoma	CCLE	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.659
p.P971S	RVH-421	skin	COSMIC	LAPSGCNRQALPL	DEG_ODPH_VHL_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPSGCNRQALPL

Degron related mutations and impact score

Drug responses associated with ZNF804B mutations

All proteins holding degron of LAPSGCNRQALPL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D1E1	Zinc finger protein 804B	DEG_ODPH_VHL_1	967:979	LAPSGCNRQALPL	VHL	0.9734	More...