DegronMD - A4FU49(SH3D21)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K376R	TCGA-61-2113	OV	TCGA	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.3056
p.K376R	DO29328	OV	ICGC	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.3056
p.A360T	TCGA-A8-A08R	BRCA	TCGA	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.0833
p.A360T	DO1255	BRCA	ICGC	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.0833
p.A371T	TCGA-AA-3968	COAD	TCGA	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation altering degron motif	0.7139
p.A371T	DO9178	COAD	ICGC	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation altering degron motif	0.7139
p.P372T	TCGA-ER-A19T	SKCM	TCGA	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation altering degron motif	0.7031
p.P372T	DO51251	SKCM	ICGC	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation altering degron motif	0.7031
p.P372H	TCGA-GN-A262	SKCM	TCGA	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation altering degron motif	0.7694
p.P372H	DO37515	SKCM	ICGC	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation altering degron motif	0.7694
p.S373G	TCGA-VQ-A8PT	STAD	TCGA	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation altering degron motif	0.6993
p.S373G	DO51776	STAD	ICGC	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation altering degron motif	0.6993
p.P384L	DO220903	MELA	ICGC	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.0833
p.E378K	SIDM00150	Colorectal Carcinoma	GDSC	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.25
p.E378K	KM12	large intestine	COSMIC	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.25
p.R382K	ACH-000840	Lung Cancer	CCLE	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.1389
p.E373K	ACH-000969	Colon/Colorectal Cancer	CCLE	VLTPELS	DEG_SCF_FBW7_1	369:375	Mutation altering degron motif	0.591

Kaplan plot for SH3D21 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH3D21

UniProt ID: A4FU49

Entrez ID: 79729

Protein name: SH3 domain-containing protein 21

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH3D21 in