DegronMD

Uniprot ID: A4FU49

Source protein: SH3 domain-containing protein 21

Source gene: SH3D21

Class: DEG_SCF_FBW7_1

Location: 369:375

E3 ligase: FBXW7

DEGRON score: 0.9936

ASA_SCORE: 90.4857

COIL: 0.9529

CONS_SCORE: 0.4267

DSS_SCORE: 0.6006

HELIX: 0.019

FCONS_SCORE: 1.1832

RIG_SCORE: 0.7296

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K376R	TCGA-61-2113	OV	TCGA	VLTPELS	DEG_SCF_FBW7_1	0.3056
p.K376R	DO29328	OV	ICGC	VLTPELS	DEG_SCF_FBW7_1	0.3056
p.A360T	TCGA-A8-A08R	BRCA	TCGA	VLTPELS	DEG_SCF_FBW7_1	0.0833
p.A360T	DO1255	BRCA	ICGC	VLTPELS	DEG_SCF_FBW7_1	0.0833
p.A371T	TCGA-AA-3968	COAD	TCGA	VLTPELS	DEG_SCF_FBW7_1	0.7139
p.A371T	DO9178	COAD	ICGC	VLTPELS	DEG_SCF_FBW7_1	0.7139
p.P372T	TCGA-ER-A19T	SKCM	TCGA	VLTPELS	DEG_SCF_FBW7_1	0.7031
p.P372T	DO51251	SKCM	ICGC	VLTPELS	DEG_SCF_FBW7_1	0.7031
p.P372H	TCGA-GN-A262	SKCM	TCGA	VLTPELS	DEG_SCF_FBW7_1	0.7694
p.P372H	DO37515	SKCM	ICGC	VLTPELS	DEG_SCF_FBW7_1	0.7694
p.S373G	TCGA-VQ-A8PT	STAD	TCGA	VLTPELS	DEG_SCF_FBW7_1	0.6993
p.S373G	DO51776	STAD	ICGC	VLTPELS	DEG_SCF_FBW7_1	0.6993
p.P384L	DO220903	MELA	ICGC	VLTPELS	DEG_SCF_FBW7_1	0.0833
p.E378K	SIDM00150	Colorectal Carcinoma	GDSC	VLTPELS	DEG_SCF_FBW7_1	0.25
p.E378K	KM12	large_intestine	COSMIC	VLTPELS	DEG_SCF_FBW7_1	0.25
p.R382K	ACH-000840	Lung Cancer	CCLE	VLTPELS	DEG_SCF_FBW7_1	0.1389
p.E373K	ACH-000969	Colon/Colorectal Cancer	CCLE	VLTPELS	DEG_SCF_FBW7_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4FU49	SH3 domain-containing protein 21	DEG_SCF_FBW7_1	369:375	VLTPELS	FBXW7	0.9936	More...
Q96DY7	Mdm2-binding protein	DEG_SCF_FBW7_1	633:639	VLTPELS	FBXW7	0.9708	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons