DegronMD - Q96DY7(MTBP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P624S	TCGA-21-1081	LUSC	TCGA	VLTPELS	DEG_SCF_FBW7_1	633:639	Mutation rewiring degron network	0.0833
p.P624S	DO26930	LUSC	ICGC	VLTPELS	DEG_SCF_FBW7_1	633:639	Mutation rewiring degron network	0.0833
p.K630N	TCGA-AX-A05Z	UCEC	TCGA	VLTPELS	DEG_SCF_FBW7_1	633:639	Mutation blocking ubiquitination signal	0.6944
p.K630N	DO40884	UCEC	ICGC	VLTPELS	DEG_SCF_FBW7_1	633:639	Mutation blocking ubiquitination signal	0.6944
p.S711L	TCGA-CV-A45O	HNSC	TCGA	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.0556
p.S711L	DO234469	ESAD	ICGC	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.0556
p.S711L	DO223124	ESCA	ICGC	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.0556
p.S711L	DO49044	HNSC	ICGC	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.0556
p.S711L	DO220856	MELA	ICGC	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.0556
p.S711L	SIDM01393	Gastric Carcinoma	GDSC	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.0556
p.R684C	TCGA-EE-A181	SKCM	TCGA	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.1111
p.R684C	DO37444	SKCM	ICGC	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.1111
p.C691R	TCGA-HF-7132	STAD	TCGA	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.3056
p.C691R	DO38214	STAD	ICGC	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.3056
p.Q644L	TCGA-L9-A7SV	LUAD	TCGA	VLTPELS	DEG_SCF_FBW7_1	633:639	Mutation rewiring degron network	0.1944
p.Q644L	DO49875	LUAD	ICGC	VLTPELS	DEG_SCF_FBW7_1	633:639	Mutation rewiring degron network	0.1944
p.R684H	TCGA-ND-A4WC	UCS	TCGA	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.1111
p.R684H	SIDM00945	Colorectal Carcinoma	GDSC	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.1111
p.R684H	ACH-000895	Colon/Colorectal Cancer	CCLE	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.1111
p.R684H	CL-34	large intestine	COSMIC	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.1111
p.L702F	TCGA-XF-AAN0	BLCA	TCGA	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.3056
p.L702F	DO51941	BLCA	ICGC	TRESFPVPTV	DEG_COP1_1	692:701	Mutation rewiring degron network	0.3056
p.E569K	DO218173	BRCA	ICGC	ERHVLQNLE	DEG_APCC_DBOX_1	558:566	Mutation rewiring degron network	0.25
p.W556C	DO229022	LICA	ICGC	ERHVLQNLE	DEG_APCC_DBOX_1	558:566	Mutation rewiring degron network	0.2778
p.F696S	DO50780	LIRI	ICGC	TRESFPVPTV	DEG_COP1_1	692:701	Mutation altering degron motif	0.6871
p.P697S	DO232224	PBCA	ICGC	TRESFPVPTV	DEG_COP1_1	692:701	Mutation altering degron motif	0.5641
p.K627R	DO38404	STAD	ICGC	VLTPELS	DEG_SCF_FBW7_1	633:639	Mutation blocking ubiquitination signal	0.6111
p.T571N	DO229275	THCA	ICGC	ERHVLQNLE	DEG_APCC_DBOX_1	558:566	Mutation rewiring degron network	0.1944
p.L548P	DO229216	THCA	ICGC	ERHVLQNLE	DEG_APCC_DBOX_1	558:566	Mutation rewiring degron network	0.0556
p.E637G	DO229248	THCA	ICGC	VLTPELS	DEG_SCF_FBW7_1	633:639	Mutation altering degron motif	0.6087
p.P624Q	SIDM00683	Prostate Carcinoma	GDSC	VLTPELS	DEG_SCF_FBW7_1	633:639	Mutation rewiring degron network	0.0833
p.P624Q	ACH-000977	lymph node	CCLE	VLTPELS	DEG_SCF_FBW7_1	633:639	Mutation rewiring degron network	0.0833
p.P624Q	LNCaP-Clone-FGC	prostate	COSMIC	VLTPELS	DEG_SCF_FBW7_1	633:639	Mutation rewiring degron network	0.0833
p.T567S	SIDM00969	Ovarian Carcinoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	558:566	Mutation rewiring degron network	0.3056
p.T567S	SIDM01126	Small Cell Lung Carcinoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	558:566	Mutation rewiring degron network	0.3056
p.T567S	SIDM00529	Breast Carcinoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	558:566	Mutation rewiring degron network	0.3056
p.T567S	SIDM00971	Breast Carcinoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	558:566	Mutation rewiring degron network	0.3056
p.T567S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	558:566	Mutation rewiring degron network	0.3056
p.T567S	SIDM00309	Mesothelioma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	558:566	Mutation rewiring degron network	0.3056
p.T567S	SIDM00844	Burkitt's Lymphoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	558:566	Mutation rewiring degron network	0.3056
p.T567S	SIDM01173	Rhabdomyosarcoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	558:566	Mutation rewiring degron network	0.3056
p.T567S	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	558:566	Mutation rewiring degron network	0.3056
p.T567S	SIDM01387	Small Cell Lung Carcinoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	558:566	Mutation rewiring degron network	0.3056
p.T700A	SIDM00282	Colorectal Carcinoma	GDSC	TRESFPVPTV	DEG_COP1_1	692:701	Mutation altering degron motif	0.7139
p.T700A	ACH-000998	Colon/Colorectal Cancer	CCLE	TRESFPVPTV	DEG_COP1_1	692:701	Mutation altering degron motif	0.7139
p.T700A	CW-2	large intestine	COSMIC	TRESFPVPTV	DEG_COP1_1	692:701	Mutation altering degron motif	0.7139
p.Q573K	ACH-001430	Bone Cancer	CCLE	ERHVLQNLE	DEG_APCC_DBOX_1	558:566	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTBP

UniProt ID: Q96DY7

Entrez ID: 27085

Protein name: Mdm2-binding protein (hMTBP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTBP in