DegronMD

Uniprot ID: Q96DY7

Source protein: Mdm2-binding protein

Source gene: MTBP

Class: DEG_COP1_1

Location: 692:701

E3 ligase: COP1

DEGRON score: 0.9931

ASA_SCORE: 98.85

COIL: 0.8694

CONS_SCORE: 0.4301

DSS_SCORE: 0.4567

HELIX: 0.0479

FCONS_SCORE: 0.7495

RIG_SCORE: 0.7643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S711L	TCGA-CV-A45O	HNSC	TCGA	TRESFPVPTV	DEG_COP1_1	0.0556
p.S711L	DO234469	ESAD	ICGC	TRESFPVPTV	DEG_COP1_1	0.0556
p.S711L	DO223124	ESCA	ICGC	TRESFPVPTV	DEG_COP1_1	0.0556
p.S711L	DO49044	HNSC	ICGC	TRESFPVPTV	DEG_COP1_1	0.0556
p.S711L	DO220856	MELA	ICGC	TRESFPVPTV	DEG_COP1_1	0.0556
p.S711L	SIDM01393	Gastric Carcinoma	GDSC	TRESFPVPTV	DEG_COP1_1	0.0556
p.R684C	TCGA-EE-A181	SKCM	TCGA	TRESFPVPTV	DEG_COP1_1	0.1111
p.R684C	DO37444	SKCM	ICGC	TRESFPVPTV	DEG_COP1_1	0.1111
p.C691R	TCGA-HF-7132	STAD	TCGA	TRESFPVPTV	DEG_COP1_1	0.3056
p.C691R	DO38214	STAD	ICGC	TRESFPVPTV	DEG_COP1_1	0.3056
p.R684H	TCGA-ND-A4WC	UCS	TCGA	TRESFPVPTV	DEG_COP1_1	0.1111
p.R684H	SIDM00945	Colorectal Carcinoma	GDSC	TRESFPVPTV	DEG_COP1_1	0.1111
p.R684H	ACH-000895	Colon/Colorectal Cancer	CCLE	TRESFPVPTV	DEG_COP1_1	0.1111
p.R684H	CL-34	large_intestine	COSMIC	TRESFPVPTV	DEG_COP1_1	0.1111
p.L702F	TCGA-XF-AAN0	BLCA	TCGA	TRESFPVPTV	DEG_COP1_1	0.3056
p.L702F	DO51941	BLCA	ICGC	TRESFPVPTV	DEG_COP1_1	0.3056
p.F696S	DO50780	LIRI	ICGC	TRESFPVPTV	DEG_COP1_1	0.6871
p.P697S	DO232224	PBCA	ICGC	TRESFPVPTV	DEG_COP1_1	0.5641
p.T700A	SIDM00282	Colorectal Carcinoma	GDSC	TRESFPVPTV	DEG_COP1_1	0.7139
p.T700A	ACH-000998	Colon/Colorectal Cancer	CCLE	TRESFPVPTV	DEG_COP1_1	0.7139
p.T700A	CW-2	large_intestine	COSMIC	TRESFPVPTV	DEG_COP1_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DY7	Mdm2-binding protein	DEG_COP1_1	692:701	TRESFPVPTV	COP1	0.9931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons