DegronMD

Uniprot ID: Q96DY7

Source protein: Mdm2-binding protein

Source gene: MTBP

Class: DEG_APCC_DBOX_1

Location: 558:566

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9846

ASA_SCORE: 69.3

COIL: 0.2754

CONS_SCORE: 0.6983

DSS_SCORE: 0.4957

HELIX: 0.6928

FCONS_SCORE: 1.4662

RIG_SCORE: 0.7848

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E569K	DO218173	BRCA	ICGC	ERHVLQNLE	DEG_APCC_DBOX_1	0.25
p.W556C	DO229022	LICA	ICGC	ERHVLQNLE	DEG_APCC_DBOX_1	0.2778
p.T571N	DO229275	THCA	ICGC	ERHVLQNLE	DEG_APCC_DBOX_1	0.1944
p.L548P	DO229216	THCA	ICGC	ERHVLQNLE	DEG_APCC_DBOX_1	0.0556
p.T567S	SIDM00969	Ovarian Carcinoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	0.3056
p.T567S	SIDM01126	Small Cell Lung Carcinoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	0.3056
p.T567S	SIDM00529	Breast Carcinoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	0.3056
p.T567S	SIDM00971	Breast Carcinoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	0.3056
p.T567S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	0.3056
p.T567S	SIDM00309	Mesothelioma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	0.3056
p.T567S	SIDM00844	Burkitt's Lymphoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	0.3056
p.T567S	SIDM01173	Rhabdomyosarcoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	0.3056
p.T567S	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	0.3056
p.T567S	SIDM01387	Small Cell Lung Carcinoma	GDSC	ERHVLQNLE	DEG_APCC_DBOX_1	0.3056
p.Q573K	ACH-001430	Bone Cancer	CCLE	ERHVLQNLE	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DY7	Mdm2-binding protein	DEG_APCC_DBOX_1	558:566	ERHVLQNLE	APC,CDC20,FZR1	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons