DegronMD

Uniprot ID: Q96DY7

Source protein: Mdm2-binding protein

Source gene: MTBP

Class: DEG_SCF_FBW7_1

Location: 633:639

E3 ligase: FBXW7

DEGRON score: 0.9708

ASA_SCORE: 62.8

COIL: 0.685

CONS_SCORE: 0.4572

DSS_SCORE: 0.2734

HELIX: 0.0423

FCONS_SCORE: 0.8711

RIG_SCORE: 0.8095

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P624S	TCGA-21-1081	LUSC	TCGA	VLTPELS	DEG_SCF_FBW7_1	0.0833
p.P624S	DO26930	LUSC	ICGC	VLTPELS	DEG_SCF_FBW7_1	0.0833
p.K630N	TCGA-AX-A05Z	UCEC	TCGA	VLTPELS	DEG_SCF_FBW7_1	0.6944
p.K630N	DO40884	UCEC	ICGC	VLTPELS	DEG_SCF_FBW7_1	0.6944
p.Q644L	TCGA-L9-A7SV	LUAD	TCGA	VLTPELS	DEG_SCF_FBW7_1	0.1944
p.Q644L	DO49875	LUAD	ICGC	VLTPELS	DEG_SCF_FBW7_1	0.1944
p.K627R	DO38404	STAD	ICGC	VLTPELS	DEG_SCF_FBW7_1	0.6111
p.E637G	DO229248	THCA	ICGC	VLTPELS	DEG_SCF_FBW7_1	0.6087
p.P624Q	SIDM00683	Prostate Carcinoma	GDSC	VLTPELS	DEG_SCF_FBW7_1	0.0833
p.P624Q	ACH-000977	lymph_node	CCLE	VLTPELS	DEG_SCF_FBW7_1	0.0833
p.P624Q	LNCaP-Clone-FGC	prostate	COSMIC	VLTPELS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4FU49	SH3 domain-containing protein 21	DEG_SCF_FBW7_1	369:375	VLTPELS	FBXW7	0.9936	More...
Q96DY7	Mdm2-binding protein	DEG_SCF_FBW7_1	633:639	VLTPELS	FBXW7	0.9708	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons