DegronMD - A4FU69(EFCAB5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P250T	TCGA-A5-A0G2	UCEC	TCGA	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.0556
p.P250S	TCGA-AP-A1E0	UCEC	TCGA	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.0556
p.P250H	TCGA-EB-A299	SKCM	TCGA	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.0556
p.P250H	DO37794	SKCM	ICGC	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.0556
p.E259D	DO8264	COAD	ICGC	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.3056
p.K250N	DO228952	LICA	ICGC	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.0556
p.Q266H	DO229015	LICA	ICGC	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.2778
p.V256F	DO229022	LICA	ICGC	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.2222
p.C254F	DO232761	PBCA	ICGC	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.1667
p.L268I	DO229227	THCA	ICGC	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.2222
p.C272Y	DO41584	UCEC	ICGC	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.1111
p.I274V	SIDM00130	Pancreatic Carcinoma	GDSC	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.0556
p.I274V	ACH-000138	Pancreatic Cancer	CCLE	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.0556
p.I274V	CFPAC-1	pancreas	COSMIC	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.0556
p.V252A	SNU-C5	large intestine	COSMIC	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation rewiring degron network	0.1111
p.P264S	C32	skin	COSMIC	MKENV	DEG_APCC_KENBOX_2	260:264	Mutation altering degron motif	0.6752

Kaplan plot for EFCAB5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EFCAB5

UniProt ID: A4FU69

Entrez ID: 374786

Protein name: EF-hand calcium-binding domain-containing protein 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EFCAB5 in