DegronMD

Uniprot ID: A4FU69

Source protein: EF-hand calcium-binding domain-containing protein 5

Source gene: EFCAB5

Class: DEG_APCC_KENBOX_2

Location: 260:264

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.552

ASA_SCORE: 99.22

COIL: 0.4396

CONS_SCORE: 0.4315

DSS_SCORE: 0.4744

HELIX: 0.5348

FCONS_SCORE: 1.1085

RIG_SCORE: 0.7953

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P250T	TCGA-A5-A0G2	UCEC	TCGA	MKENV	DEG_APCC_KENBOX_2	0.0556
p.P250S	TCGA-AP-A1E0	UCEC	TCGA	MKENV	DEG_APCC_KENBOX_2	0.0556
p.P250H	TCGA-EB-A299	SKCM	TCGA	MKENV	DEG_APCC_KENBOX_2	0.0556
p.P250H	DO37794	SKCM	ICGC	MKENV	DEG_APCC_KENBOX_2	0.0556
p.E259D	DO8264	COAD	ICGC	MKENV	DEG_APCC_KENBOX_2	0.3056
p.K250N	DO228952	LICA	ICGC	MKENV	DEG_APCC_KENBOX_2	0.0556
p.Q266H	DO229015	LICA	ICGC	MKENV	DEG_APCC_KENBOX_2	0.2778
p.V256F	DO229022	LICA	ICGC	MKENV	DEG_APCC_KENBOX_2	0.2222
p.C254F	DO232761	PBCA	ICGC	MKENV	DEG_APCC_KENBOX_2	0.1667
p.L268I	DO229227	THCA	ICGC	MKENV	DEG_APCC_KENBOX_2	0.2222
p.C272Y	DO41584	UCEC	ICGC	MKENV	DEG_APCC_KENBOX_2	0.1111
p.I274V	SIDM00130	Pancreatic Carcinoma	GDSC	MKENV	DEG_APCC_KENBOX_2	0.0556
p.I274V	ACH-000138	Pancreatic Cancer	CCLE	MKENV	DEG_APCC_KENBOX_2	0.0556
p.I274V	CFPAC-1	pancreas	COSMIC	MKENV	DEG_APCC_KENBOX_2	0.0556
p.V252A	SNU-C5	large_intestine	COSMIC	MKENV	DEG_APCC_KENBOX_2	0.1111
p.P264S	C32	skin	COSMIC	MKENV	DEG_APCC_KENBOX_2	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P83111	Serine beta-lactamase-like protein LACTB, mitochondrial	DEG_APCC_KENBOX_2	242:246	MKENV	APC,CDC20,FZR1	0.7634	More...
A4FU69	EF-hand calcium-binding domain-containing protein 5	DEG_APCC_KENBOX_2	260:264	MKENV	APC,CDC20,FZR1	0.552	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons