DegronMD - P83111(LACTB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M241L	TCGA-AN-A0XV	BRCA	TCGA	MKENV	DEG_APCC_KENBOX_2	242:246	Mutation rewiring degron network	0.3056
p.M241L	DO2913	BRCA	ICGC	MKENV	DEG_APCC_KENBOX_2	242:246	Mutation rewiring degron network	0.3056
p.E232K	TCGA-D5-5541	COAD	TCGA	MKENV	DEG_APCC_KENBOX_2	242:246	Mutation rewiring degron network	0.0556
p.E232K	DO10475	COAD	ICGC	MKENV	DEG_APCC_KENBOX_2	242:246	Mutation rewiring degron network	0.0556
p.A238S	DO228976	LICA	ICGC	MKENV	DEG_APCC_KENBOX_2	242:246	Mutation rewiring degron network	0.2222
p.R24P	DO229031	LICA	ICGC	QRAGLPPLG	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.1944
p.H38Y	DO229257	THCA	ICGC	QRAGLPPLG	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.3056
p.R25C	SIDM00672	Hepatocellular Carcinoma	GDSC	QRAGLPPLG	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.2222
p.R25C	SIDM00845	Burkitt's Lymphoma	GDSC	QRAGLPPLG	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.2222
p.R25C	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	QRAGLPPLG	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.2222
p.R25C	SIDM00068	Colorectal Carcinoma	GDSC	QRAGLPPLG	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.2222
p.R25C	SIDM00808	Burkitt's Lymphoma	GDSC	QRAGLPPLG	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.2222
p.R25C	SIDM01387	Small Cell Lung Carcinoma	GDSC	QRAGLPPLG	DEG_APCC_DBOX_1	29:37	Mutation rewiring degron network	0.2222
p.K234I	SIDM00789	Colorectal Carcinoma	GDSC	MKENV	DEG_APCC_KENBOX_2	242:246	Mutation substituting flanking lysine	0.2222
p.K234I	HCT-15	large intestine	COSMIC	MKENV	DEG_APCC_KENBOX_2	242:246	Mutation substituting flanking lysine	0.2222
p.P34R	SIDM00846	Cervical Carcinoma	GDSC	QRAGLPPLG	DEG_APCC_DBOX_1	29:37	Mutation altering degron motif	0.6401
p.Q250H	ACH-001119	Lymphoma	CCLE	MKENV	DEG_APCC_KENBOX_2	242:246	Mutation rewiring degron network	0.2222

Kaplan plot for LACTB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LACTB

UniProt ID: P83111

Entrez ID: 114294

Protein name: Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LACTB in