DegronMD

Uniprot ID: P83111

Source protein: Serine beta-lactamase-like protein LACTB, mitochondrial

Source gene: LACTB

Class: DEG_APCC_KENBOX_2

Location: 242:246

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7634

ASA_SCORE: 76.04

COIL: 0.4882

CONS_SCORE: 0.1074

DSS_SCORE: 0.3768

HELIX: 0.4764

FCONS_SCORE: 1.0754

RIG_SCORE: 0.7915

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M241L	TCGA-AN-A0XV	BRCA	TCGA	MKENV	DEG_APCC_KENBOX_2	0.3056
p.M241L	DO2913	BRCA	ICGC	MKENV	DEG_APCC_KENBOX_2	0.3056
p.E232K	TCGA-D5-5541	COAD	TCGA	MKENV	DEG_APCC_KENBOX_2	0.0556
p.E232K	DO10475	COAD	ICGC	MKENV	DEG_APCC_KENBOX_2	0.0556
p.A238S	DO228976	LICA	ICGC	MKENV	DEG_APCC_KENBOX_2	0.2222
p.K234I	SIDM00789	Colorectal Carcinoma	GDSC	MKENV	DEG_APCC_KENBOX_2	0.2222
p.K234I	HCT-15	large_intestine	COSMIC	MKENV	DEG_APCC_KENBOX_2	0.2222
p.Q250H	ACH-001119	Lymphoma	CCLE	MKENV	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P83111	Serine beta-lactamase-like protein LACTB, mitochondrial	DEG_APCC_KENBOX_2	242:246	MKENV	APC,CDC20,FZR1	0.7634	More...
A4FU69	EF-hand calcium-binding domain-containing protein 5	DEG_APCC_KENBOX_2	260:264	MKENV	APC,CDC20,FZR1	0.552	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons