DegronMD

Uniprot ID: P83111

Source protein: Serine beta-lactamase-like protein LACTB, mitochondrial

Source gene: LACTB

Class: DEG_APCC_DBOX_1

Location: 29:37

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8656

ASA_SCORE: 58.2778

COIL: 0.7977

CONS_SCORE: 0.3727

DSS_SCORE: 0.2976

HELIX: 0.1291

FCONS_SCORE: 1.2624

RIG_SCORE: 0.6975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R24P	DO229031	LICA	ICGC	QRAGLPPLG	DEG_APCC_DBOX_1	0.1944
p.H38Y	DO229257	THCA	ICGC	QRAGLPPLG	DEG_APCC_DBOX_1	0.3056
p.R25C	SIDM00672	Hepatocellular Carcinoma	GDSC	QRAGLPPLG	DEG_APCC_DBOX_1	0.2222
p.R25C	SIDM00845	Burkitt's Lymphoma	GDSC	QRAGLPPLG	DEG_APCC_DBOX_1	0.2222
p.R25C	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	QRAGLPPLG	DEG_APCC_DBOX_1	0.2222
p.R25C	SIDM00068	Colorectal Carcinoma	GDSC	QRAGLPPLG	DEG_APCC_DBOX_1	0.2222
p.R25C	SIDM00808	Burkitt's Lymphoma	GDSC	QRAGLPPLG	DEG_APCC_DBOX_1	0.2222
p.R25C	SIDM01387	Small Cell Lung Carcinoma	GDSC	QRAGLPPLG	DEG_APCC_DBOX_1	0.2222
p.P34R	SIDM00846	Cervical Carcinoma	GDSC	QRAGLPPLG	DEG_APCC_DBOX_1	0.6401

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P83111	Serine beta-lactamase-like protein LACTB, mitochondrial	DEG_APCC_DBOX_1	29:37	QRAGLPPLG	APC,CDC20,FZR1	0.8656	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons