DegronMD - A5LHX3(PSMB11)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E278G	TCGA-A5-A1OF	UCEC	TCGA	VTPGDS	DEG_SCF_FBW7_1	286:291	Mutation rewiring degron network	0.1111
p.E278G	DO42568	UCEC	ICGC	VTPGDS	DEG_SCF_FBW7_1	286:291	Mutation rewiring degron network	0.1111
p.T299M	TCGA-IE-A4EH	SARC	TCGA	VTPGDS	DEG_SCF_FBW7_1	286:291	Mutation rewiring degron network	0.1111
p.T299M	DO220151	SARC	ICGC	VTPGDS	DEG_SCF_FBW7_1	286:291	Mutation rewiring degron network	0.1111
p.T299M	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	VTPGDS	DEG_SCF_FBW7_1	286:291	Mutation rewiring degron network	0.1111
p.T299M	ACH-000860	Lung Cancer	CCLE	VTPGDS	DEG_SCF_FBW7_1	286:291	Mutation rewiring degron network	0.1111
p.T299M	NCI-H358	lung	COSMIC	VTPGDS	DEG_SCF_FBW7_1	286:291	Mutation rewiring degron network	0.1111
p.S291C	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	VTPGDS	DEG_SCF_FBW7_1	286:291	Mutation altering degron motif	0.7541
p.S291C	ACH-000875	Lung Cancer	CCLE	VTPGDS	DEG_SCF_FBW7_1	286:291	Mutation altering degron motif	0.7541
p.S291C	NCI-H2347	lung	COSMIC	VTPGDS	DEG_SCF_FBW7_1	286:291	Mutation altering degron motif	0.7541

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons