DegronMD

Uniprot ID: A5LHX3

Source protein: Proteasome subunit beta type-11

Source gene: PSMB11

Class: DEG_SCF_FBW7_1

Location: 286:291

E3 ligase: FBXW7

DEGRON score: 0.986

ASA_SCORE: 61.2167

COIL: 0.7297

CONS_SCORE: 0.4296

DSS_SCORE: 0.7812

HELIX: 0.0355

FCONS_SCORE: 1.0844

RIG_SCORE: 0.6083

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E278G	TCGA-A5-A1OF	UCEC	TCGA	VTPGDS	DEG_SCF_FBW7_1	0.1111
p.E278G	DO42568	UCEC	ICGC	VTPGDS	DEG_SCF_FBW7_1	0.1111
p.T299M	TCGA-IE-A4EH	SARC	TCGA	VTPGDS	DEG_SCF_FBW7_1	0.1111
p.T299M	DO220151	SARC	ICGC	VTPGDS	DEG_SCF_FBW7_1	0.1111
p.T299M	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	VTPGDS	DEG_SCF_FBW7_1	0.1111
p.T299M	ACH-000860	Lung Cancer	CCLE	VTPGDS	DEG_SCF_FBW7_1	0.1111
p.T299M	NCI-H358	lung	COSMIC	VTPGDS	DEG_SCF_FBW7_1	0.1111
p.S291C	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	VTPGDS	DEG_SCF_FBW7_1	0.7541
p.S291C	ACH-000875	Lung Cancer	CCLE	VTPGDS	DEG_SCF_FBW7_1	0.7541
p.S291C	NCI-H2347	lung	COSMIC	VTPGDS	DEG_SCF_FBW7_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5LHX3	Proteasome subunit beta type-11	DEG_SCF_FBW7_1	286:291	VTPGDS	FBXW7	0.986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons