DegronMD - A5PLN9(TRAPPC13)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R249C	TCGA-A5-A1OF	UCEC	TCGA	TRQYLYCLK	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.8301
p.R240T	TCGA-L3-A524	LUSC	TCGA	TRQYLYCLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.1111
p.Y251C	DO233773	GACA	ICGC	TRQYLYCLK	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.5976
p.A241S	DO228971	LICA	ICGC	TRQYLYCLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.1389
p.G238W	DO229038	LICA	ICGC	TRQYLYCLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.0556
p.R243C	DO42568	UCEC	ICGC	TRQYLYCLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.1944
p.P245L	SIDM00683	Prostate Carcinoma	GDSC	TRQYLYCLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.25
p.P245L	ACH-000977	lymph node	CCLE	TRQYLYCLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.25
p.P245L	LNCaP-Clone-FGC	prostate	COSMIC	TRQYLYCLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.25
p.K258N	SIDM01588	Endometrial Carcinoma	GDSC	TRQYLYCLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.2778
p.K258N	ACH-000993	Endometrial/Uterine Cancer	CCLE	TRQYLYCLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.2778
p.P239L	LNCaP-Clone-FGC	prostate	COSMIC	TRQYLYCLK	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons