DegronMD

Uniprot ID: A5PLN9

Source protein: Trafficking protein particle complex subunit 13

Source gene: TRAPPC13

Class: DEG_APCC_DBOX_1

Location: 248:256

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5205

ASA_SCORE: 43.3444

COIL: 0.3492

CONS_SCORE: 0.5946

DSS_SCORE: 0.1393

HELIX: 0.0922

FCONS_SCORE: 1.7369

RIG_SCORE: 0.9311

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R249C	TCGA-A5-A1OF	UCEC	TCGA	TRQYLYCLK	DEG_APCC_DBOX_1	0.8301
p.R240T	TCGA-L3-A524	LUSC	TCGA	TRQYLYCLK	DEG_APCC_DBOX_1	0.1111
p.Y251C	DO233773	GACA	ICGC	TRQYLYCLK	DEG_APCC_DBOX_1	0.5976
p.A241S	DO228971	LICA	ICGC	TRQYLYCLK	DEG_APCC_DBOX_1	0.1389
p.G238W	DO229038	LICA	ICGC	TRQYLYCLK	DEG_APCC_DBOX_1	0.0556
p.R243C	DO42568	UCEC	ICGC	TRQYLYCLK	DEG_APCC_DBOX_1	0.1944
p.P245L	SIDM00683	Prostate Carcinoma	GDSC	TRQYLYCLK	DEG_APCC_DBOX_1	0.25
p.P245L	ACH-000977	lymph_node	CCLE	TRQYLYCLK	DEG_APCC_DBOX_1	0.25
p.P245L	LNCaP-Clone-FGC	prostate	COSMIC	TRQYLYCLK	DEG_APCC_DBOX_1	0.25
p.K258N	SIDM01588	Endometrial Carcinoma	GDSC	TRQYLYCLK	DEG_APCC_DBOX_1	0.2778
p.K258N	ACH-000993	Endometrial/Uterine Cancer	CCLE	TRQYLYCLK	DEG_APCC_DBOX_1	0.2778
p.P239L	LNCaP-Clone-FGC	prostate	COSMIC	TRQYLYCLK	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5PLN9	Trafficking protein particle complex subunit 13	DEG_APCC_DBOX_1	248:256	TRQYLYCLK	APC,CDC20,FZR1	0.5205	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons