DegronMD - A6H8M9(CDHR4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A754V	TCGA-A7-A13E	BRCA	TCGA	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.1944
p.A754V	DO2659	BRCA	ICGC	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.1944
p.S756N	TCGA-AA-3864	COAD	TCGA	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.25
p.S756N	DO8490	COAD	ICGC	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.25
p.G773R	TCGA-AJ-A3BH	UCEC	TCGA	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.0833
p.G773R	DO41638	UCEC	ICGC	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.0833
p.Q768H	TCGA-AP-A059	UCEC	TCGA	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.2222
p.Q768H	DO41361	UCEC	ICGC	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.2222
p.A754T	TCGA-E6-A1LX	UCEC	TCGA	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.1944
p.A754T	DO41020	UCEC	ICGC	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.1944
p.G765V	TCGA-EO-A3KX	UCEC	TCGA	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.3056
p.G765V	DO219774	UCEC	ICGC	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.3056
p.F763L	TCGA-FI-A2D5	UCEC	TCGA	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation altering degron motif	0.587
p.F763L	DO41331	UCEC	ICGC	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation altering degron motif	0.587
p.V758A	TCGA-FI-A2D5	UCEC	TCGA	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.3056
p.V758A	DO41331	UCEC	ICGC	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.3056
p.S756I	TCGA-FI-A2D5	UCEC	TCGA	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.25
p.S756I	DO41331	UCEC	ICGC	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.25
p.A767V	DO230342	COCA	ICGC	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation rewiring degron network	0.25
p.M759V	DO229221	THCA	ICGC	MSLHFD	LIG_APCC_ABBA_1	759:764	Mutation altering degron motif	0.6097

Kaplan plot for CDHR4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDHR4

UniProt ID: A6H8M9

Entrez ID: 389118

Protein name: Cadherin-related family member 4 (Cadherin-like protein 29)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDHR4 in