DegronMD

Uniprot ID: A6H8M9

Source protein: Cadherin-related family member 4

Source gene: CDHR4

Class: LIG_APCC_ABBA_1

Location: 759:764

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.801

ASA_SCORE: 68.1333

COIL: 0.3773

CONS_SCORE: 0.8574

DSS_SCORE: 0.5213

HELIX: 0.006

FCONS_SCORE: 1.0998

RIG_SCORE: 0.7255

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A754V	TCGA-A7-A13E	BRCA	TCGA	MSLHFD	LIG_APCC_ABBA_1	0.1944
p.A754V	DO2659	BRCA	ICGC	MSLHFD	LIG_APCC_ABBA_1	0.1944
p.S756N	TCGA-AA-3864	COAD	TCGA	MSLHFD	LIG_APCC_ABBA_1	0.25
p.S756N	DO8490	COAD	ICGC	MSLHFD	LIG_APCC_ABBA_1	0.25
p.G773R	TCGA-AJ-A3BH	UCEC	TCGA	MSLHFD	LIG_APCC_ABBA_1	0.0833
p.G773R	DO41638	UCEC	ICGC	MSLHFD	LIG_APCC_ABBA_1	0.0833
p.Q768H	TCGA-AP-A059	UCEC	TCGA	MSLHFD	LIG_APCC_ABBA_1	0.2222
p.Q768H	DO41361	UCEC	ICGC	MSLHFD	LIG_APCC_ABBA_1	0.2222
p.A754T	TCGA-E6-A1LX	UCEC	TCGA	MSLHFD	LIG_APCC_ABBA_1	0.1944
p.A754T	DO41020	UCEC	ICGC	MSLHFD	LIG_APCC_ABBA_1	0.1944
p.G765V	TCGA-EO-A3KX	UCEC	TCGA	MSLHFD	LIG_APCC_ABBA_1	0.3056
p.G765V	DO219774	UCEC	ICGC	MSLHFD	LIG_APCC_ABBA_1	0.3056
p.F763L	TCGA-FI-A2D5	UCEC	TCGA	MSLHFD	LIG_APCC_ABBA_1	0.587
p.F763L	DO41331	UCEC	ICGC	MSLHFD	LIG_APCC_ABBA_1	0.587
p.V758A	TCGA-FI-A2D5	UCEC	TCGA	MSLHFD	LIG_APCC_ABBA_1	0.3056
p.V758A	DO41331	UCEC	ICGC	MSLHFD	LIG_APCC_ABBA_1	0.3056
p.S756I	TCGA-FI-A2D5	UCEC	TCGA	MSLHFD	LIG_APCC_ABBA_1	0.25
p.S756I	DO41331	UCEC	ICGC	MSLHFD	LIG_APCC_ABBA_1	0.25
p.A767V	DO230342	COCA	ICGC	MSLHFD	LIG_APCC_ABBA_1	0.25
p.M759V	DO229221	THCA	ICGC	MSLHFD	LIG_APCC_ABBA_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6H8M9	Cadherin-related family member 4	LIG_APCC_ABBA_1	759:764	MSLHFD	APC,CDC20,FZR1	0.801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons