DegronMD - A6NDA9(LRIT2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V13I	TCGA-59-2351	OV	TCGA	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation altering degron motif	0.5965
p.V13I	DO31240	OV	ICGC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation altering degron motif	0.5965
p.A19T	TCGA-AA-3877	COAD	TCGA	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.25
p.A19T	DO7855	COAD	ICGC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.25
p.V13A	TCGA-AA-A00N	COAD	TCGA	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation altering degron motif	0.6936
p.V13A	DO9876	COAD	ICGC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation altering degron motif	0.6936
p.L10F	TCGA-AB-2851	LAML	TCGA	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.3056
p.L10F	DO21785	LAML	ICGC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.3056
p.L10F	SIDM00193	Colorectal Carcinoma	GDSC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.3056
p.L10F	ACH-000991	Colon/Colorectal Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.3056
p.L10F	SNU-81	large intestine	COSMIC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.3056
p.L25M	TCGA-AP-A1DV	UCEC	TCGA	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.0833
p.L25M	DO43186	UCEC	ICGC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.0833
p.P26Q	TCGA-D3-A2JP	SKCM	TCGA	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.0556
p.P26Q	DO47407	SKCM	ICGC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.0556
p.H18N	DO229027	LICA	ICGC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.2778
p.Q21E	SIDM00402	Bladder Carcinoma	GDSC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.1944
p.Q21E	ACH-000473	Bladder Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.1944
p.Q21E	ACH-001183	Bladder Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.1944
p.Q21E	RT-112	urinary tract	COSMIC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.1944
p.F14S	SIDM00596	Endometrial Carcinoma	GDSC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation altering degron motif	0.7982
p.F14S	ACH-000941	Endometrial/Uterine Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation altering degron motif	0.7982
p.F14S	ACH-000954	Endometrial/Uterine Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation altering degron motif	0.7982
p.F14S	ACH-001517	Endometrial/Uterine Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation altering degron motif	0.7982
p.F14S	HEC-1	endometrium	COSMIC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation altering degron motif	0.7982
p.H6D	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.1944
p.H6D	ACH-000888	Lung Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.1944
p.H6D	NCI-H1793	lung	COSMIC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.1944
p.S3P	SIDM01609	Endometrial Carcinoma	GDSC	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.1111
p.S3P	ACH-000972	Endometrial/Uterine Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	11:16	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRIT2

UniProt ID: A6NDA9

Entrez ID: 340745

Protein name: Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 (Leucine-rich repeat-containing protein 22)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRIT2 in