DegronMD

Uniprot ID: A6NDA9

Source protein: Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2

Source gene: LRIT2

Class: LIG_APCC_ABBA_1

Location: 11:16

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5923

ASA_SCORE: 76.2167

COIL: 0.436

CONS_SCORE: 0.4501

DSS_SCORE: 0.0005

HELIX: 0.4963

FCONS_SCORE: 1.1708

RIG_SCORE: 0.9762

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V13I	TCGA-59-2351	OV	TCGA	VLVFLD	LIG_APCC_ABBA_1	0.5965
p.V13I	DO31240	OV	ICGC	VLVFLD	LIG_APCC_ABBA_1	0.5965
p.A19T	TCGA-AA-3877	COAD	TCGA	VLVFLD	LIG_APCC_ABBA_1	0.25
p.A19T	DO7855	COAD	ICGC	VLVFLD	LIG_APCC_ABBA_1	0.25
p.V13A	TCGA-AA-A00N	COAD	TCGA	VLVFLD	LIG_APCC_ABBA_1	0.6936
p.V13A	DO9876	COAD	ICGC	VLVFLD	LIG_APCC_ABBA_1	0.6936
p.L10F	TCGA-AB-2851	LAML	TCGA	VLVFLD	LIG_APCC_ABBA_1	0.3056
p.L10F	DO21785	LAML	ICGC	VLVFLD	LIG_APCC_ABBA_1	0.3056
p.L10F	SIDM00193	Colorectal Carcinoma	GDSC	VLVFLD	LIG_APCC_ABBA_1	0.3056
p.L10F	ACH-000991	Colon/Colorectal Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	0.3056
p.L10F	SNU-81	large_intestine	COSMIC	VLVFLD	LIG_APCC_ABBA_1	0.3056
p.L25M	TCGA-AP-A1DV	UCEC	TCGA	VLVFLD	LIG_APCC_ABBA_1	0.0833
p.L25M	DO43186	UCEC	ICGC	VLVFLD	LIG_APCC_ABBA_1	0.0833
p.P26Q	TCGA-D3-A2JP	SKCM	TCGA	VLVFLD	LIG_APCC_ABBA_1	0.0556
p.P26Q	DO47407	SKCM	ICGC	VLVFLD	LIG_APCC_ABBA_1	0.0556
p.H18N	DO229027	LICA	ICGC	VLVFLD	LIG_APCC_ABBA_1	0.2778
p.Q21E	SIDM00402	Bladder Carcinoma	GDSC	VLVFLD	LIG_APCC_ABBA_1	0.1944
p.Q21E	ACH-000473	Bladder Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	0.1944
p.Q21E	ACH-001183	Bladder Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	0.1944
p.Q21E	RT-112	urinary_tract	COSMIC	VLVFLD	LIG_APCC_ABBA_1	0.1944
p.F14S	SIDM00596	Endometrial Carcinoma	GDSC	VLVFLD	LIG_APCC_ABBA_1	0.7982
p.F14S	ACH-000941	Endometrial/Uterine Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	0.7982
p.F14S	ACH-000954	Endometrial/Uterine Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	0.7982
p.F14S	ACH-001517	Endometrial/Uterine Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	0.7982
p.F14S	HEC-1	endometrium	COSMIC	VLVFLD	LIG_APCC_ABBA_1	0.7982
p.H6D	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	VLVFLD	LIG_APCC_ABBA_1	0.1944
p.H6D	ACH-000888	Lung Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	0.1944
p.H6D	NCI-H1793	lung	COSMIC	VLVFLD	LIG_APCC_ABBA_1	0.1944
p.S3P	SIDM01609	Endometrial Carcinoma	GDSC	VLVFLD	LIG_APCC_ABBA_1	0.1111
p.S3P	ACH-000972	Endometrial/Uterine Cancer	CCLE	VLVFLD	LIG_APCC_ABBA_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLVFLD

Degron related mutations and impact score

Drug responses associated with LRIT2 mutations

All proteins holding degron of VLVFLD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDA9	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2	LIG_APCC_ABBA_1	11:16	VLVFLD	APC,CDC20,FZR1	0.5923	More...